{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T08:57:59Z","timestamp":1698569879598},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":3276,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An <jats:italic>ex vivo<\/jats:italic> model of a perfused canine tibia was used to investigate the effect of human adrenomedullin, a novel peptide with known vasodilator properties, on the vascular resistance of bone. Human adrenomedullin has a potent and long\u2010lasting vasodilator effect in the canine tibia following precontraction of vascular smooth muscle by infusion of prostaglandin F<jats:sub>2\u03b1<\/jats:sub>. A 0.1 ml bolus injection of 10<jats:sup>\u22125<\/jats:sup> <jats:italic>M<\/jats:italic> human adrenomedullin suppressed the pressor response of the canine tibia preparation to an infusion of norepinephrine by 43\u201352% for a duration of 100 minutes. An injection of 10<jats:sup>\u22126<\/jats:sup> adrenomedullin suppressed the pressor response to an infusion of norepinephrine by 22\u201323% for a duration of 40 minutes. These data suggest that human adrenomedullin may be a potent and long\u2010acting vascular smooth\u2010muscle relaxant in bone.<\/jats:p>","DOI":"10.1002\/jor.1100140224","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T11:04:50Z","timestamp":1109243090000},"page":"329-333","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of human adrenomedullin on vascular resistance of the canine tibia"],"prefix":"10.1002","volume":"14","author":[{"given":"Teiji","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen T.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090615"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100118"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100306"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1302\/0301-620X.71B3.2722923","article-title":"Bone changes in the vascularised fibular graft","volume":"71","author":"de Boer HM","year":"1989","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_6_2","first-page":"H904","article-title":"Vascular reactivity of the isolated tibia of the dog","volume":"236","author":"Driessens M","year":"1979","journal-title":"Am J Physiol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(94)00844-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90214-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1496"},{"issue":"3","key":"e_1_2_1_11_2","first-page":"H671","article-title":"Endotheliumdependent contraction to stretch in canine basilar arteries","volume":"252","author":"Katusic ZS","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1451"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197802000-00017"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a071482"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100610"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2241"},{"key":"e_1_2_1_17_2","first-page":"H95","article-title":"Bioassay of endothelium\u2010derived relaxing factor(s): inactivation by catecholamines","volume":"249","author":"Rubanyi GM","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2132"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(94)00652-0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080219"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100140224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100140224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T16:53:40Z","timestamp":1698339220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100140224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["10.1002\/jor.1100140224"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100140224","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]},"assertion":[{"value":"1995-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}