{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:33:13Z","timestamp":1790519593433,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":3154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rotator cuff and biceps tendons that appeared grossly normal were procured from adult cadavers without a history of shoulder problems. These tendons were analyzed for the amount and type of glycosaminoglycan, type of proteoglycan, and histology. When compared with the distal\/tensional region of biceps tendon, the glycosaminoglycan content of supraspinatus, infraspinatus, and subscapularis tendons was 2.5\u2010fold higher and the glycosaminoglycan content of the proximal\/compressed region of biceps tendon was 3\u2010fold higher. The ratio of hyaluronic acid to chondroitin sulfate\/dermatan sulfate in all three cuff tendons was approximately 1. Rotator cuff tendons contained large proteoglycan similar to aggrecan, as demonstrated by sodium dodecyl sulfate\u2010polyacrylamide gel migration, elution from Sepharose CL\u20104B, and content of both chondroitin sulfate and keratan sulfate chains. Both decorin and biglycan were also present, as demonstrated by migration in sodium dodecyl sulfate\u2010polyacrylamide gels and core protein immunoreactivity. In contrast, decorin was the only proteoglycan prominent in distal\/tensional regions of biceps tendon. Histological analysis showed layers of loosely organized, alcian blue\u2010stained material running between the longitudinal collagen fiber bundles. The proteoglycan content of rotator cuff tendons was similar to fibrocartilage in tendons that have been subjected to compressive loads <jats:italic>in situ<\/jats:italic>. This suggests that cells of normal adult rotator cuff tendons have adapted to loads distinct from pure tension. However, the histological organization did not resemble mature fibrocartilage. The increased amount of proteoglycan in rotator cuff tendons may serve to separate and lubricate collagen bundles as they move relative to each other during normal shoulder motion.<\/jats:p>","DOI":"10.1002\/jor.1100140404","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T10:53:12Z","timestamp":1109242392000},"page":"518-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Proteoglycans of human rotator cuff tendons"],"prefix":"10.1002","volume":"14","author":[{"given":"Matthew C.","family":"Berenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Field T.","family":"Blevins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna H. K.","family":"Plaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn G.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2106\/00004623-199072080-00011","article-title":"Arthroscopic acromioplasty: technique and results","volume":"72","author":"Altchek DW","year":"1990","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"Cell and matrix changes associated with pathological calcification of the human rotator cuff tendons","volume":"182","author":"Archer RS","year":"1993","journal-title":"J Anat"},{"key":"e_1_2_1_4_2","first-page":"1","article-title":"Fibrocartilage","volume":"171","author":"Benjamin M","year":"1990","journal-title":"J Anat"},{"key":"e_1_2_1_5_2","first-page":"625","article-title":"Fibrocartilage associated with human tendons and their pulleys","volume":"187","author":"Benjamin M","year":"1995","journal-title":"J Anat"},{"key":"e_1_2_1_6_2","first-page":"216","article-title":"The morphology of the acromion and its relationship to rotator cuff tears","volume":"10","author":"Bigliani LU","year":"1986","journal-title":"Orthop Trans"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080102"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1302\/0301-620X.74B1.1732247","article-title":"A quantitative histological study of the vascularity of the rotator cuff tendon","volume":"74","author":"Brooks CH","year":"1992","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_9_2","first-page":"269","article-title":"Determination of pentose in the presence of large quantities of glucose","volume":"11","author":"Brown AH","year":"1946","journal-title":"Arch Biochem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.1.30"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199274050-00010"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100130211"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1574"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1630145"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008207909152351"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100110413"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2920661"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-9602(11)80420-6"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100050314"},{"key":"e_1_2_1_20_2","first-page":"38","article-title":"Identification and partial characterization of small proteoglycan (PGII) lacking glycosaminoglycan in tendon","volume":"15","author":"Koob TJ","year":"1990","journal-title":"Trans Orthop Res"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90127-I"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/4.3.333"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008209309032929"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197254010-00003"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00003086-199005000-00006","article-title":"Acromial enthesopathy and rotator cuff tear: a radiologic and histologic postmortem investigation of the coracoacromial arch","volume":"254","author":"Ogata S","year":"1990","journal-title":"Clin Orthop"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100050209"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1002\/j.1460-2075.1989.tb08399.x","article-title":"A collagen\u2010binding 59\u2010kd protein (fibromodulin) is structurally related to the small interstitial proteoglycan PG\u2010S1 and PG\u2010S2 (decorin)","volume":"8","author":"Olberg A","year":"1989","journal-title":"EMBO J"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/978-3-642-67138-8_14","volume-title":"Biomechanics of the Locomotor Apparatus","author":"Pauwels F","year":"1980"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092310204"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00185920"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1302\/0301-620X.52B3.540","article-title":"The microvascular pattern of the rotator cuff","volume":"52","author":"Rathbun JB","year":"1970","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.6.367"},{"key":"e_1_2_1_33_2","first-page":"264","article-title":"Regional expression of mRNA for proteoglycans and collagen in tendon","volume":"64","author":"Robbins JR","year":"1994","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-196500410-00020"},{"key":"e_1_2_1_35_2","first-page":"420","article-title":"Structure of fibromodulin in human articular cartilage","volume":"20","author":"Roughley PJ","year":"1995","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100130414"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_1_38_2","doi-asserted-by":"crossref","first-page":"9298","DOI":"10.1016\/S0021-9258(17)39366-3","article-title":"Characterization of proteoglycans from adult bovine tendon","volume":"260","author":"Vogel KG","year":"1985","journal-title":"J Biol Chem"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60632-4"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100110109"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0945-053X(94)90006-X"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199503000-00006"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100140404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100140404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T19:02:39Z","timestamp":1698346959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100140404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1002\/jor.1100140404"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100140404","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]},"assertion":[{"value":"1995-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}