{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T05:16:29Z","timestamp":1698556589190},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":2850,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The karyotypes of 14 patients with Paget's disease of bone were studied. The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups. None of the patients were related to one another, nor had any had the same lifelong environment. Thus, 57% of a sample of active patients with Paget's disease had Robertsonian translocations. By comparison, an age and sex\u2010matched group of eight controls and 13 patients with osteoporosis who had been treated with bisphosphonates demonstrated no Robertsonian translocations. The prevalence of Robertsonian translocations in 14,000 newborns was reported to be 0.1%. These data suggest that a factor from the environment introduced during the lifetime of the patient could be present and could, in addition to genetic factors, affect gene replication during the development of Paget's disease.<\/jats:p>","DOI":"10.1002\/jor.1100150324","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T10:47:47Z","timestamp":1109242067000},"page":"477-481","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Robertsonian translocations in Paget's disease of bone"],"prefix":"10.1002","volume":"15","author":[{"given":"Barbara G.","family":"Mills","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Oizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rude","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"379","volume-title":"The ACT Cytogenetics Laboratory Manual","author":"Barch MJ","year":"1991"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-5-907"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1996.tb01180.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(94)90040-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb01498.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000149318"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000130881"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1128\/jvi.65.12.6581-6588.1991","article-title":"Human, cytomegalovirus productively infects primary differentiated macrophages","volume":"65","author":"Ibanez CE","year":"1991","journal-title":"J Virol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.61.11.3441-3447.1987"},{"key":"e_1_2_1_11_2","first-page":"51","volume-title":"Cancer Surveys: Molecular Mechanisms of the Immune Respbnse","author":"McMichal A","year":"1995"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959849"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(85)90009-2"},{"key":"e_1_2_1_14_2","first-page":"194","volume-title":"Bone: The Osteoclast","author":"Mills BG","year":"1991"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(94)90823-0"},{"key":"e_1_2_1_16_2","first-page":"1579","article-title":"Paget's disease of bone is associated with abnormal osteoclast formation in vitro and differential expression of a novel human gene which regulates mitosis","volume":"11","author":"Ralston SH","year":"1996","journal-title":"J Bone Miner Res"},{"key":"e_1_2_1_17_2","first-page":"1299","article-title":"[Nuclear anomalies in osteoclasts in Paget's bone disease.] [French]","volume":"3","author":"Rebel A","year":"1974","journal-title":"Nouv Presse Med"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050270202"},{"key":"e_1_2_1_19_2","first-page":"67","volume-title":"Cancer: Principles and Practice of Oncology","author":"Rowley JD","year":"1993"},{"key":"e_1_2_1_20_2","unstructured":"SingerFR MillsBG.ParkMS TakemuraS.TerasakiP:Increased HLA\u2010DqWl antigen frequency in Paget's disease of bone. 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