{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:25:09Z","timestamp":1790324709419,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":2789,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuropathic arthropathy is a severe chronic degenerative condition associated with decreased or absent I sensory innervation of the involved joint. Existing animal models of neuropathic arthritis are limited by the technical difficulties of obtaining either highly selective or complete joint denervation in a minimally invasive fashion. We undertook experiments to determine the feasibility of using the newly described method of selective neuronal lesioning with injected immunotoxin as a means of creating a more tractable model of neuropathic arthritis. Retrograde tracing with fluorochrome revealed that the knee joint of the female Wistar rat is supplied by 581 \u00b1 31 (mean \u00b1 SD) joint afferents. Immunohistochemistry confirmed that virtually all sensory neurons in the rat express the cell surface receptor Thy I. Injection of rat knee joints with an immunotoxin targeted toward Thy 1 resulted in the selective ablation of an average of 88% of the joint afferents identified with fluorochroime that are normally found in the ipsilateral L3 and L4 ganglia.<\/jats:p>","DOI":"10.1002\/jor.1100150420","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T10:47:51Z","timestamp":1109242071000},"page":"622-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Selective ablation of rat knee joint innervation with injected immunotoxin: A potential new model for the study of neuropathic arthritis"],"prefix":"10.1002","volume":"15","author":[{"given":"Paul T.","family":"Salo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Theriault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"Wiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"161","article-title":"Sur quelques arthropathies qui paraissent d\u00e9pendre, d'une lesion du cerveau ou de la moelle \u00e9pini\u00e8reT","volume":"1","author":"Charcot JM","year":"1868","journal-title":"Arch Physiol Norm Pathol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(90)90123-W"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00915.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0307-742X(21)00540-3","article-title":"Pathogenetic mechanisms in polyarticula osteoarthritis","volume":"11","author":"Cooke TDV","year":"1985","journal-title":"Clin Rheum Dis"},{"key":"e_1_2_1_6_2","first-page":"103","article-title":"On the nature of arthritis","volume":"10","author":"Farfan HF","year":"1983","journal-title":"J Rheumalo"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300811"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00003086-199311000-00009","article-title":"A short history of neuropathic arthropathy","volume":"296","author":"Gupta R","year":"1993","journal-title":"Clin Orthop"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/df9500900436"},{"key":"e_1_2_1_10_2","first-page":"667","article-title":"Fusimotor reflexes in triceps surae muscle elicited by natural and electrical stimulation of joint afferents","volume":"6","author":"Johansson H","year":"1988","journal-title":"Neuro\u2010Orthop"},{"key":"e_1_2_1_11_2","first-page":"9","article-title":"Reflex actions on the \u03b3\u2010muscle\u2010spindle systems of muscles acting at the knee joint elicited by stretch of the posterior cruciate ligament","volume":"8","author":"Johansson H","year":"1989","journal-title":"Neuro\u2010Orthop"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00232202"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90835-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380810"},{"key":"e_1_2_1_15_2","volume-title":"Basic Data on Arthritis of the Knee, Hip and Sacroiliac Joints in Adults Ages 25\u201374 Years, United States","author":"National Center for Health Statistics","year":"1971"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2106\/00004623-198567040-00010","article-title":"Neurogenic acceleration of degenerative joint lesions","volume":"67","author":"O'Connor BL","year":"1985","journal-title":"J Hone Joint Surg [Am]"},{"issue":"4","key":"e_1_2_1_17_2","first-page":"S106","article-title":"The development of experimental osteoarthritis in dogs with extensively deafferented knee joints","volume":"31","author":"O'Connor BL","year":"1989","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2106\/00004623-199274030-00007","article-title":"Neurogenic acceleration of osteoarthrosis: the effects of previous neurectomy of the articular nerves of the development of osteoarthritis after transection of the anterior cruciate ligament in dogs","volume":"74","author":"Connor BL","year":"1992","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0889-857X(21)00333-1","article-title":"Neurogenic factors in the etiopathogenesis of osteoarthritis","volume":"19","author":"O'Connor BL","year":"1993","journal-title":"Rheum Dis Clin North Am"},{"issue":"9","key":"e_1_2_1_20_2","first-page":"20","article-title":"The relationship between biological and mechanical factors in the aetiology of osteoarthritis","volume":"10","author":"Radin EL","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090312"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490350609"},{"key":"e_1_2_1_23_2","first-page":"515","article-title":"Number, distribution and neuropeptide content of rat knee joint afferents","volume":"190","author":"Salo PT","year":"1997","journal-title":"J Anal"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91199-6"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330109"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2160617"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90114-5"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91199-B"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90078-M"},{"key":"e_1_2_1_30_2","volume-title":"Suicide Transport and Immunolesioning","author":"Wiley RG","year":"1994"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100150420","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100150420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T22:42:48Z","timestamp":1698446568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100150420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["10.1002\/jor.1100150420"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100150420","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7]]},"assertion":[{"value":"1996-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}