{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:31:51Z","timestamp":1791246711088,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":2666,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluated the effects of combining antibiotic therapy with the application of a nonsteroidal anti\u2010inflammatory drug on the degradation of articular cartilage for an animal model of Staphylococcal septic arthritis. Rabbits were infected intra\u2010articularly with <jats:italic>Staphylococcus aureus<\/jats:italic>. Antibiotic treatment started 18 hours after infection and continued for 7 days. Treatment with the nonsteroidal anti\u2010inflammatory drug naproxen sodium started 24 hours before infection and continued for either 3 or 7 weeks. The cartilage matrix of uninfected and infected knees was quantified by analysis of glycosaminoglycan and collagen content. Three weeks after infection, the combined treatment of the nonsteroidal anti\u2010inflammatory drug and antibiotics reduced the loss of glycosaminoglycan and collagen from the cartage of the infected knee by 15 and 30%, respectively, compared with antibiotic treatment alone. Continuing treatment with naproxen sodium for 7 weeks reduced the loss of collagen by 50% when compared with antibiotic treatment alone. The longer period of treatment with naproxen sodium showed little further effect on the loss of glycosaminoglycan than that observed for the 3\u2010week treatment. Treatment with this drug and antibiotics reduced swelling of the knee and levels of prostaglandin E<jats:sub>2<\/jats:sub> in the synovial fluid. The data support the hypothesis that decreasing post\u2010infectious inflammation by adding the drug to a standard antibiotic regimen reduces cartilage damage from Staphylococcal septic arthritis.<\/jats:p>","DOI":"10.1002\/jor.1100150619","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T10:52:25Z","timestamp":1109242345000},"page":"919-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Staphylococcal septic arthritis: Antibiotic and nonsteroidal anti\u2010inflammatory drug treatment in a rabbit model"],"prefix":"10.1002","volume":"15","author":[{"given":"R. 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