{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:13:00Z","timestamp":1758474780037},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":1997,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1999,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was conducted to elucidate the role of the cytokine interleukin\u20101 beta on peripheral nerve recovery following crush injuries of wo different magnitudes. Eighty\u2010eight female rats were divided into four groups. A 5\u2010mm segment of the right sciatic nerve was subjected to a 100\u2010g crush load for 2 hours in the rats in Groups A1 and B1 or to a 15,000\u2010g crush load for 10 minutes in the rats in Groups A2 and B2. The rats in Groups A1 and A2 received 10 \u03bcg\/100 g body weight human recombinant interleukin\u20101 beta intraperitoneally 48, 24, and 1 hours before the nerve injury. The rats in Groups B1 and B2 were treated with an equal volume of normal saline solution with identical schedule guidelines. Walking\u2010track tests (sciatic functional index) performed at intervals until 56 days after the crush and measurements of the contractile force of the extensor digitorum longus muscle made until 28 days were used to evaluate functional recovery of the nerve. During the second week after injury, the rats treated with interleukin\u20101 beta (A1) had an earlier recovery on the walking track than did those treated with saline solution (B1); this difference reached significance (p &lt; 0.05) at day 11. Although Group A2 demonstrated a trend toward earlier recovery compared with Group B2, there was no significant difference between the two groups. After low or high\u2010load crush injury, tetanic contractile forces were greater in the rats treated with human recombinant interleukin\u20101 beta than in those treated with saline solution. The results suggest that treatment with human recombinant interleukin\u20101 beta before crush injury can promote function in the peripheral nerve after the injury. However, the mechanisms that underlie the observed beneficial effects are not completely understood and only speculations can be made.<\/jats:p>","DOI":"10.1002\/jor.1100170514","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T10:32:02Z","timestamp":1109241122000},"page":"714-719","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interleukin\u20101 beta promotes functional recovery of crushed peripheral nerve"],"prefix":"10.1002","volume":"17","author":[{"given":"Anastasios V.","family":"Korompilias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long\u2010En","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony V.","family":"Seaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James 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