{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:16:28Z","timestamp":1767626188468},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":1936,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From 1986 to 1992, 88 patients with articular defects in the knee were treated with a perichondrial arthroplasty. In this study, we report on the results for 22 biopsies of grafted tissue with a mean follow\u2010up of 21 months. Biopsies were obtained at routine arthroscopy after approximately 1 year or at arthroscopy or arthrotomy at a later stage when patients were operated on again because of recurrent complaints. Biopsies were taken only when a partial failure was present or when there was a clear failure resulting in fibrocartilage, a loose flap, or a loose body. The biopsies were analyzed histologically, biochemically for the amount of type\u2010II collagen, and immunohistochemically with antibodies for types I, II, and X collagen. The well\u2010being of the patients was investigated with use of the Hospital for Special Surgery knee score. The biopsies from 6 patients contained more than 50% hyaline cartilage. At arthroscopy, the mean relative amount of type\u2010II collagen was 56% in the biopsies classified as good. The cartilage of the grafted area was macroscopically normal for eight of the 22 biopsies. Histological and biochemical analysis of biopsies from failed transplants showed fibrocartilage with mainly type\u2010I collagen. These tissues were retrieved primarily from patients with additional abnormalities in the knee joint. It was concluded that adult human perichondrium is able to form hyaline\u2010like cartilage in an isolated cartilage defect in an otherwise healthy knee.<\/jats:p>","DOI":"10.1002\/jor.1100170609","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T10:32:37Z","timestamp":1109241157000},"page":"843-849","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Histological and biochemical evaluation of perichondrial transplants in human articular cartilage defects"],"prefix":"10.1002","volume":"17","author":[{"given":"Phianne","family":"Bouwmeester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roel","family":"Kuijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Terwindt\u2010Rouwenhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ton","family":"van der Linden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjoerd","family":"Bulstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008208809019070"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002640050175"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01607131"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080304"},{"key":"e_1_2_1_6_2","first-page":"45","article-title":"The healing of cartilage defects","volume":"64","author":"Campbell CJ","year":"1969","journal-title":"Clin Orthop"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197201000-00033"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00003086-199202000-00040","article-title":"Rib periochondrial autografts in full\u2010thickness articular cartilage defects in rabbits","volume":"275","author":"Coutts RD","year":"1992","journal-title":"Clin Orthop"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114215"},{"key":"e_1_2_1_10_2","first-page":"229","article-title":"Process of repair of articular cartilage demonstrated by histology and autoradiography with tritiated thymidine","volume":"48","author":"DePalma AF","year":"1966","journal-title":"Clin Orthop"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/02844317509022867"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/02844317909013069"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/02844317909013085"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062010-00012"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678909149287"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1302\/0301-620X.72B6.2246280","article-title":"Perichondrial grafting for cartilage lesions of the knee","volume":"72","author":"Homminga GN","year":"1990","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453679108996635"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199702000-00004"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020802631968"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1991.tb15852.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(85)80026-1"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658020-00012"},{"key":"e_1_2_1_23_2","first-page":"247","article-title":"Mechanisms of failure of cartilage repair procedures in humans: histological analysis of retrieved tissue","volume":"22","author":"Nehrer S","year":"1997","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_24_2","first-page":"360","article-title":"A method for quantitative analysis of ratios of types I and II collagen in small samples of articular cartilage [published erratum appears in","volume":"174","author":"O'Driscoll SW","year":"1988","journal-title":"Anal Biochem"},{"key":"e_1_2_1_24_3","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90362-8"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19990305)44:3<308::AID-JBM9>3.0.CO;2-Q"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062080-00002"},{"key":"e_1_2_1_27_2","first-page":"63","article-title":"Histochemical studies on regeneration of articular cartilage","volume":"18","author":"Tanaka H","year":"1971","journal-title":"Tokushima J Exp Med"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350715"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.3109\/02844318609004483"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.8.1850705"},{"key":"e_1_2_1_31_2","first-page":"267","article-title":"Cellular origin and evolution of neochondrogenesis in major fullthickness defects of a joint surface treated by free autogenous periosteal grafts and subjected to continuous passive motion in rabbits","volume":"222","author":"Zanett R","year":"1987","journal-title":"Clin Orthop"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100170609","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100170609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:13:46Z","timestamp":1698574426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100170609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["10.1002\/jor.1100170609"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100170609","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]},"assertion":[{"value":"1998-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}