{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:16:40Z","timestamp":1698643000460},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":1693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Resective distraction osteogenesis is a new approach to treat segmental diaphyseal bone defects by primary limb shortening and secondary distraction osteogenesis from the same site. A rabbit model was introduced to compare the bone\u2010regeneration characteristics of this technique with those of simple lengthening procedures. Twenty\u2010four skeletally mature New Zealand White rabbits were divided into two equal groups. In the test group, limbs were lengthened after a 10\u2010mm segmental diaphyseal bone resection and limb shortening. In the control group, a simple subperiosteal osteotomy for limb lengthening was performed without resection. New bone formation was evaluated mechanically, radiologically, histomorphometrically, and densitometrically. Bone bridging occurred in all animals. Normalized mechanical values for the newly reconstructed tibiae demonstrated similar torsional stiffness (71 \u00b1 3.3 compared with 71 \u00b1 8.2%; p = 0.95) and strength (64 \u00b1 5.3 compared with 68 \u00b1 7.3%; p = 0.66) in the two groups. The average normalized callus diameter was significantly greater in the test group than in the control group (p &lt; 0.01). The remodeling index calculated from densitometry, however, showed a significantly less progressed stage of remodeling in the test group (p &lt; 0.05). Histomorphometric analysis of the callus center supported this finding, showing significantly lower values for trabecular thickness (p &lt; 0.05) and total bone volume (p &lt; 0.01) in the test group. The results demonstrated the possibility of new bone formation after resection and monofocal shortening. This suggests a new therapeutic option to treat diaphyseal segmental bone defects.<\/jats:p>","DOI":"10.1002\/jor.1100180416","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T14:41:52Z","timestamp":1109256112000},"page":"629-636","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Primary resective shortening followed by distraction osteogenesis for limb reconstruction: A comparison with simple lengthening"],"prefix":"10.1002","volume":"18","author":[{"given":"Rainer H.","family":"Meffert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Tis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward F.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Brug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund Y. 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