{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:25:03Z","timestamp":1769106303316,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":1693,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many biomechanical studies are performed on dense connective tissues in the laboratory over a substantial time period; however, the effect of the <jats:italic>in vitro<\/jats:italic> testing environment on the cyclic load\u2010relaxation behaviour of these structures is not well established. This study evaluated the effect of long duration of testing on ligament viscoelastic behaviour, using the rabbit femur\u2010medial collateral ligament\u2010tibia complex as a model. Dissected rabbit knee joints were mounted on a materials testing machine, and isolated ligament complexes were cycled at a frequency of one cycle\/min to a fixed displacement of 0.7 mm for an 18\u2010hour period. After an initial period of exponential load relaxation, the cyclic peak loads slowly decreased over the 18\u2010hour period. The average decrease in the cyclic peak load between 0.5 and 18.0 hours was 0.26% (of the original peak load) per hour (r<jats:sup>2<\/jats:sup> = 0.934), or a total of 8.6 \u00b1 4.6% over this period (p &lt; 0.0001). Thus, lowload testing of dense connective tissues in the laboratory over extended periods significantly alters their biomechanical behaviour, and these changes should be considered in long\u2010term laboratory\u2010based studies of dense connective tissues.<\/jats:p>","DOI":"10.1002\/jor.1100180422","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T14:41:52Z","timestamp":1109256112000},"page":"678-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of <i>in vitro<\/i> testing over extended periods on the low\u2010load mechanical behaviour of dense connective tissues"],"prefix":"10.1002","volume":"18","author":[{"given":"Graham J. W.","family":"King","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrie L.","family":"Pillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(92)90223-N"},{"key":"e_1_2_1_3_2","first-page":"45","volume-title":"Injury and Repair of Musculoskeletal Soft Tissues","author":"Frank C","year":"1988"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1973-10208"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080409"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199407000-00007"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.2891165"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(93)90609-I"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3233\/BIR-1988-25401","article-title":"Physico\u2010chemical and micro\u2010structural changes in collagen fiber bundles following stretch in\u2010vitro","volume":"25","author":"Lanir Y","year":"1988","journal-title":"Biorheology"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.3138295"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.3138645"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100180422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100180422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T12:24:29Z","timestamp":1698582269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100180422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1002\/jor.1100180422"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100180422","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]},"assertion":[{"value":"1998-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}