{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:33:53Z","timestamp":1769214833215,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":1570,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the concept of using plates to attach endoprostheses to bone after segmental resection for bone tumours in an animal model. Titanium alloy plates integrated with the prosthesis and coated with hydroxyapatite were attached to bone by screws. This type of uncemented fixation relied on the induction of periosteal bone formation into and around the plates to secure the implant to bone. Tow, three, and six\u2010slotted plate designs were investigated. On retrieval, each plate was securely fixed by new bone. Bone apposition on the external surface of the plates occurred through a combination of periosteal bone production, invasion of bone through slots in the plate, and bone growth over the ends of the plates. Most plates became incorporated into a remodelled cortex. Higher bone turnover rates (\u03bcm day<jats:sup>\u22121<\/jats:sup>) were seen in bone in the slots of the plate compared with normal cortical bone turnover (p &lt; 0.05). Significantly higher rates of turnover were measured beneath slotted parts of the plates compared with regions below the unslotted parts (p &lt; 0.05). The cross\u2010sectional area of bone surrounding the six\u2010plate implant design was significantly higher than that of the three\u2010plate (p &lt; 0.05) and two\u2010plate (p &lt; 0.05) designs. In addition, significantly more bone formed adjacent to the six\u2010plated implant design compared with that in the contralateral limb (p = 0.002). However, no significant difference was found when the total cortical area around the three\u2010plated design was compared with that of the contralateral limb (p = 0.63). In contrast, significantly less bone was measured adjacent to the two\u2010plate design than in the untreated limb (p = 0.001). Image analysis also demonstrated increased cortical porosity adjacent to the six\u2010plate design compared with the three\u2010plate (p = 0.004) and two\u2010plate (p &lt; 0.05) designs. Finite element analysis demonstrated that the six and three\u2010plate designs increased the second moment of area compared with that in the left tibia (p = 0.003 and 0.066, respectively). However, the attachment of the more flexible two\u2010plate design did not significantly increase the second moment of area compared with that in the contralateral limb (p = 0.235). It was concluded that due to both mechanical and biological effects, the hydroxyapatite\u2010coated plate designs generated new bone that enhanced fixation and encouraged plate integration into the load\u2010bearing structure of the cortex. This method of fixation may be an alternative to the use of intramedullary cemented stems in patients requiring bone tumour implants and may be the only way to preserve the joint in difficult cases where only short segments of bone remain.<\/jats:p>","DOI":"10.1002\/jor.1100180604","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T14:48:01Z","timestamp":1109256481000},"page":"865-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Plate Fixation of Prostheses after Segmental Resection for Bone Tumours"],"prefix":"10.1002","volume":"18","author":[{"given":"Melanie J.","family":"Coathup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin P.","family":"Cobb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon W.","family":"Blunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677608991984"},{"key":"e_1_2_1_3_2","unstructured":"Animal Scientific Procedures Acta London UK (ISBN 0 10 541486 7) Her Majesty's Stationery Office 1986"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199805000-00011"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-68072-7_6"},{"key":"e_1_2_1_6_2","first-page":"395","volume-title":"Basic Orthopaedic Biomechanics","author":"Huiskes R","year":"1997"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(84)90078-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.3928\/0147-7447-19861201-07","article-title":"A modular femur tibia reconstruction system","volume":"9","author":"Kotz R","year":"1986","journal-title":"Orthopaedics"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199711000-00026"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(05)80177-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2106\/00004623-198870020-00002","article-title":"Comparison of replacement prostheses for segmental defects in bone: different porous coatings for extracortical fixation","volume":"70","author":"Okada Y","year":"1988","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00003086-198807000-00018","article-title":"Early temporary porosis of bone induced by internal fixation implants: a reaction to necrosis, not to stress protection?","volume":"232","author":"Perren SM","year":"1988","journal-title":"Clin Orthop"},{"key":"e_1_2_1_13_2","first-page":"244","article-title":"Strain gauge analysis of bone response to internal fixation","volume":"132","author":"Schatzker J","year":"1978","journal-title":"Clin Orthop"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1302\/0301-620X.76B1.8300684","article-title":"Composition and morphology of wear debris in failed uncemented total hip replacements","volume":"76","author":"Shanhag AS","year":"1994","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198264070-00003"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199608000-00009"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199711000-00016"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(96)00141-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199410000-00010"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(06)80087-2"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.78B1.0780005"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199307000-00003"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(97)90003-6"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658020-00005"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100180604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100180604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T18:16:01Z","timestamp":1698603361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100180604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1002\/jor.1100180604"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100180604","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]},"assertion":[{"value":"1999-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}