{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:54:10Z","timestamp":1761512050737},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":1570,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low back pain is a common problem, affecting approximately two\u2010thirds of the adult population. Of these individuals, a significant percentage will exhibit symptoms of radicular pain or sciatica. The purpose of this study was to determine the effect of one systemic (2 mg\/kg) or intrathecal (0.2 mg\/kg) dose of a selective cyclooxygenase\u20102 inhibitor (SC\u2010236) in decreasing existing mechanical allodynia in a rat model of radiculopathy. Gait disturbance and mechanical allodynia (increased response to non\u2010noxious von Frey monofilament stimuli) were assessed daily until the rats were killed 7 days after surgery. Robust mechanical allodynia developed in the rats in all groups except for those in the sham group by day 1 after surgery. Mechanical allodynia was significantly lower in the rats that received the systemic or the intrathecal dose of SC\u2010236 than in those in the vehicle control group (analysis of variance followed by Bonferroni multiple comparison test, p = 0.002). The intrathecal drug route of administration produced greater attenuation in allodynia than the systemic dose, supporting a central mechanism of action of the cyclooxygenase\u20102 inhibitor (p = 0.002). The hypothesis that cyclooxygenase\u20102 is involved in spinal nociceptive processing after a nerve root injury was supported by this study. In addition, these data support continued basic science research to further elucidate central inflammatory processes that follow nerve root injury.<\/jats:p>","DOI":"10.1002\/jor.1100180618","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T14:48:01Z","timestamp":1109256481000},"page":"977-982","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cyclooxygenase\u20102 inhibitor SC\u2010236 attenuates mechanical allodynia following nerve root injury in rats"],"prefix":"10.1002","volume":"18","author":[{"given":"Joyce A.","family":"DeLeo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria D.","family":"Rutkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James N.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00726.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_1_4_2","unstructured":"BerdeC SundelR: COX\u20102 inhibitors: a status report.IASP NewsletterSept\u2010Oct 1998"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00119-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7065"},{"key":"e_1_2_1_7_2","first-page":"163","volume-title":"Low Back Pain: A Scientific and Clinical Overview","author":"DeLeo JA","year":"1996"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1996.16.695"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00209-6"},{"key":"e_1_2_1_10_2","first-page":"1031","article-title":"Effect of COX\u20101 and COX\u20102 inhibition on induction and maintenance of carrageenanevoked thermal hyperalgesia in rats","volume":"285","author":"Dirig DM","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970505)381:2<119::AID-CNE1>3.0.CO;2-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199610)18:2<152::AID-GLIA7>3.0.CO;2-2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1810-9_45"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200005150-00003"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00281-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199703240-00038"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00598-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199804150-00008"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1998.0731"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","unstructured":"HoiseJ DistelM BluhmkiE: Meloxicam in osteoarthritis: a 6\u2010month double\u2010blind comparison with diclofenac sodium.Br J Rheumatol(35 Suppl):39\u201343 1996","DOI":"10.1093\/rheumatology\/35.suppl_1.39"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(77)90033-1"},{"key":"e_1_2_1_22_2","volume-title":"Expression of cell adhesion molecules, MHC 11 and CD4 in the spinal cord of rats in a model for lumbar radiculopathy","author":"Hunt J","year":"2000"},{"key":"e_1_2_1_23_2","volume-title":"A new model for lumbar radiculopathy in the rat","author":"Hunt J","year":"2000"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199602010-00003"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199408150-00001"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199705150-00004"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1097\/00007632-199611150-00002","article-title":"Incision of the annulus fibrosus induces nerve root morphologic, vascular, and functional changes: an experimental study","volume":"21","author":"Kayama S","year":"1996","journal-title":"Spine"},{"issue":"49","key":"e_1_2_1_28_2","first-page":"9","article-title":"Outcome of specific COX\u20102 inhibition in rheumatoid arthritis","volume":"24","author":"Lipsky PE","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198710000-00009"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM193408022110506"},{"issue":"4","key":"e_1_2_1_31_2","first-page":"6","article-title":"The discovery and function of COX\u20102","volume":"24","author":"Needleman P","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevNeurobiol.v13.i1.30"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199318110-00005"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00119-5"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5325-0_24"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(74)90163-0"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199707070-00018"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100180618","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100180618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T18:17:22Z","timestamp":1698603442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100180618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1002\/jor.1100180618"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100180618","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]},"assertion":[{"value":"1999-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}