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The behavior of CoCr pellets immersed in human serum, foetal bovine serum (FBS), synovial fluid, albumin in phosphate\u2010buffered saline (PBS), EDTA in PBS, and water were studied using X\u2010ray Photoelectron Spectroscopy (XPS) and Time\u2010of\u2010Flight Secondary Ion Mass Spectroscopy (ToF\u2010SIMS). The difference in the corrosive nature of human serum, water, albumin in PBS and synovial fluid after 5 days of immersion was highlighted by the oxide layer, which was respectively 15, 3.5, 1.5, and 1.5 nm thick. The thickness of an additional calcium phosphate deposit from human serum and synovial fluid was 40 and 2 nm, respectively. Co and Cr ions migrated from the bulk metal surface and were trapped in this deposit by the phosphate anion. This may account for the composition of wear debris from CoCr orthopedic implants, which is known to consist predominantly of hydroxy\u2010phosphate compounds. Known components of synovial fluid including proteoglycans, pyrophosphates, phospholipids, lubricin, and superficial zone protein (SZP), have been identified as possible causes for the lack of significant calcium phosphate deposition in this environment. Circulation of these compounds around the whole implant may inhibit calcium phosphate deposition. \u00a9 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:1587\u20131596, 2006<\/jats:p>","DOI":"10.1002\/jor.20198","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T18:09:15Z","timestamp":1150394955000},"page":"1587-1596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The entrapment of corrosion products from CoCr implant alloys in the deposits of calcium phosphate: A comparison of serum, synovial fluid, albumin, EDTA, and water"],"prefix":"10.1002","volume":"24","author":[{"given":"A. 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