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The authors hypothesized that SIS treatment of full\u2010thickness muscle belly lacerations would significantly improve muscle function, strength, and regeneration compared to the current standard\u2010of\u2010care treatment. Muscle belly lacerations were created in the extensor digitorum longus (EDL) of both hind limbs of each rabbit. After randomization, lacerations were left unrepaired (<jats:italic>n<\/jats:italic>\u2009=\u200948) or repaired using a 4\u20100 Prolene modified Kessler stitch (<jats:italic>n<\/jats:italic>\u2009=\u200948). A flap of SIS graft was sutured into half (<jats:italic>n<\/jats:italic>\u2009=\u200924 each) of the repaired and unrepaired muscles forming four study groups. Suture repair with SIS augmentation of complete muscle lacerations resulted in healed tissue that most closely resembled normal muscle in terms of morphology and function when compared to current standard\u2010of\u2010care treatments. Active force production in this group reached 79% of uninjured controls 12 weeks after surgery. SIS may have important clinical advantages over suture repair alone and warrants further clinical study. \u00a9 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 2007<\/jats:p>","DOI":"10.1002\/jor.20232","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T18:58:56Z","timestamp":1163789936000},"page":"396-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of a novel biomaterial for intrasubstance muscle laceration repair"],"prefix":"10.1002","volume":"25","author":[{"given":"Bradley D.","family":"Crow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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