{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:23:53Z","timestamp":1762100633316},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T00:00:00Z","timestamp":1170892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diminished healing in neuropathic tissues suggests an important regulatory role for peripheral neurogenic factors in connective tissue healing. Although neurogenic factors, including neuropeptides, can induce cell proliferation and influence inflammatory cell chemotaxis in vitro, there is little appreciation of the potential of neuropeptides to affect connective tissue healing in vivo. We created both efferent and afferent peripheral neuropathies in 55 female Wistar rats. First, we showed that neuropathy led to impaired healing of ruptured ligaments. We then showed that local delivery of specific neuropeptides could reverse the functional deficits of these neuropathic ligaments in only 2 weeks. In substance P and vasoactive intestinal peptide\u2010treated medial collateral ligaments (MCLs), the mechanical properties of these healing neuropathic tissues returned to values at or above normally innervated, intact ligaments. In addition, neuropeptide Y stimulated MCL healing in this model. These findings suggest a new paradigm to improve neuropathic soft connective tissue healing. \u00a9 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25: 703\u2013712, 2007<\/jats:p>","DOI":"10.1002\/jor.20335","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T19:16:29Z","timestamp":1170962189000},"page":"703-712","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adjuvant neuropeptides can improve neuropathic ligament healing in a rat model"],"prefix":"10.1002","volume":"25","author":[{"given":"Kelley W.","family":"Grorud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina T.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo P.","family":"Provenzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Ray","family":"Vanderby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.10.1107"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.5.946"},{"key":"e_1_2_1_4_2","unstructured":"Stroke NIoNDa.2001.Pain\u2014hope through research."},{"key":"e_1_2_1_5_2","unstructured":"Stroke NIoNDa.2001.Reflex sympathetic dystrophy\/complex regional pain syndrome."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00207-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199609000-00004"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.3.199"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00012-H"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430220202"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90146-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00307.2003"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90094-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90101-3"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00026-8"},{"key":"e_1_2_1_16_2","unstructured":"Stroke NIoNDa.2001.NINDS Diabetic Neuropathy Information Page."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200007000-00024"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00045-1"},{"key":"e_1_2_1_19_2","first-page":"2535","article-title":"Sympathetic stimulation of corneal epithelial proliferation in wounded and nonwounded rat eyes","volume":"37","author":"Jones MA","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199610)169:1<159::AID-JCP16>3.0.CO;2-8"},{"key":"e_1_2_1_21_2","first-page":"739","article-title":"Osobennosti techeniia ranevogo protsessa u spontanno gipertenzivnykh krys i vliianie morfina, substantsii P i ee fragmenta SP1\u20104","volume":"107","author":"Spevak SE","year":"1989","journal-title":"Biull Eksp Biol Med"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1135965100"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701265"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.9.3299"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.2.187"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199907130-00012"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(00)90029-9"},{"key":"e_1_2_1_28_2","volume-title":"Neuropeptides, nociception and pain","author":"Hokfelt T","year":"1994"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(86)90016-3"},{"key":"e_1_2_1_30_2","unstructured":"DwyerKW ProvenzanoP JensenKT et al.2003.Inhibition of peripheral nervous system alters ligament healing. Proceedings of the ASME Bioengineering Meeting Key Biscayne FL."},{"key":"e_1_2_1_31_2","unstructured":"ProvenzanoPP MartinezDA GrindelandRE et al.2001.The effect of hindlimb unloading on the healing medial collateral ligament. Proceedings of the BMES Meeting Durham NC."},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.2798284"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00032-3"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465980260041401"},{"key":"e_1_2_1_35_2","unstructured":"ProvenzanoPP MartinezDA GrindelandRE et al.2003.Insulin\u2010like growth factor\u20101 improves mechanical properties in healing ligament. Presented at the 49th Annual Meeting of the Orthopaedic Research Society New Orleans LA."},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10114"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10115"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465030310050501"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.11.005"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.20335","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.20335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:16:07Z","timestamp":1700028967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.20335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,8]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1002\/jor.20335"],"URL":"https:\/\/doi.org\/10.1002\/jor.20335","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,8]]},"assertion":[{"value":"2006-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}