{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:15:29Z","timestamp":1793452529465,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T00:00:00Z","timestamp":1175731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Material available for research into osteochondrosis (OC) in humans tends to represent chronic lesions. Comparative studies of early lesions in young animals are, therefore, important in clarifying the pathogenesis of OC in humans. Recent studies in pigs provide strong evidence that lesions of articular OC are associated with a focal failure in the cartilage canal vascular supply to epiphyseal growth cartilage (articular\u2013epiphyseal cartilage complex excluding the articular cartilage). The purpose of the present study was to examine histological sections from a specific predilection site for articular OC in the distal tibia of a large number of young foals to determine if the same is true in horses. Material from the distal tibiae of 100 foals aged from 191 days of gestation to 153 days old was collected from routine submissions of fetuses and foals for post mortem examination. The tibiae were band\u2010sawed into slabs, and selected slabs were processed for histology, stained with hematoxylin and eosin, and examined using light microscopy. Early subclinical developmental stages of OC were found in the most common site for clinical OC lesions of horses in nine of 100 foals aged 12 to 122 days old. All lesions contained areas of chondrocyte necrosis that were associated with cartilage canal necrosis in five of nine foals. Five of these foals also had focal disruption of enchondral ossification at the chondro\u2013osseous junction in the same site. Early lesions purported to play a role in the initial stages of articular OC in the distal tibia of horses were characterized by chondrocyte necrosis and likely occurred secondary to a failure of cartilage canal vascular supply to epiphyseal growth cartilage. The similarities in appearance between early lesions of piglets and foals suggest that information gained in one species may be transferable to others, including humans. \u00a9 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1094\u20131105, 2007<\/jats:p>","DOI":"10.1002\/jor.20375","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T20:20:08Z","timestamp":1175804408000},"page":"1094-1105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Early lesions of osteochondrosis in the distal tibia of foals"],"prefix":"10.1002","volume":"25","author":[{"given":"Kristin","family":"Olstad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rnar","family":"Ytrehus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stina","family":"Ekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"S. Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils I.","family":"Dolvik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"299","article-title":"The nature of osteochondrosis in animals. Summary and conclusions with comparative aspects on osteochondritis dissecans in man","volume":"358","author":"Olsson SE","year":"1978","journal-title":"Acta Radiol Suppl"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199603000-00018"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(98)50002-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090303"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.07.011"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.08.016"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400203"},{"key":"e_1_2_1_9_2","first-page":"726","article-title":"Chondrolysis associated with cartilage canals of the epiphyseal cartilage of the distal humerus of growing pigs","volume":"46","author":"Kincaid SA","year":"1985","journal-title":"Am J Vet Res"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2460\/javma.1993.203.01.101","article-title":"Heritability estimations of osteochondrosis in the tibiotarsal joint and of bony fragments in the palmar\/plantar portion of the metacarpo\u2010 and metatarsophalangeal joints of horses","volume":"203","author":"Gr\u00f8ndahl AM","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1991.tb02746.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.2042-3306.1999.tb05308.x","article-title":"Radiographic development of osteochondral abnormalities, in the hock and stifle of Dutch Warmblood foals, from age 1 to 11 months","author":"Dik KJ","year":"1999","journal-title":"Equine Vet J"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(96)80014-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(05)80008-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1997.tb03139.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589503200605"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.03.006"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107687807100906"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(82)80040-3"},{"key":"e_1_2_1_20_2","first-page":"306","article-title":"Ultrastructure of normal epiphyseal cartilage of the articular\u2013epiphyseal cartilage complex in growing swine","volume":"46","author":"Carlson CS","year":"1985","journal-title":"Am J Vet Res"},{"key":"e_1_2_1_21_2","first-page":"3","volume-title":"Robbins basic pathology","author":"Mitchell RN","year":"2003"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2000.0409"},{"key":"e_1_2_1_23_2","first-page":"113","article-title":"Osteochondrosis in the horse","volume":"56","author":"Rooney JR","year":"1975","journal-title":"Mod Vet Pract"},{"key":"e_1_2_1_24_2","first-page":"133","article-title":"Experimental osteochondritis dissecans\u2014The role of cartilage canals in chondral fractures of young rabbits","volume":"87","author":"Bravo C","year":"1996","journal-title":"Fukuoka Igaku Zasshi"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589202900605"},{"key":"e_1_2_1_26_2","first-page":"41","article-title":"Osteochondrosis in the horse","volume":"56","author":"Rooney JR","year":"1975","journal-title":"Mod Vet Pract"},{"key":"e_1_2_1_27_2","first-page":"153","article-title":"Osteochondrosis in the horse. II. Pathology","volume":"358","author":"Rejn\u00f6 S","year":"1978","journal-title":"Acta Radiol Suppl"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1979.tb01346.x"},{"key":"e_1_2_1_29_2","first-page":"43","article-title":"Bog spavin and tibiotarsal joint lesions in the horse","volume":"54","author":"Rooney JR","year":"1973","journal-title":"Mod Vet Pract"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.32B2.204"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1302\/0301-620X.41B2.375","article-title":"Multiple ossification centres in the epiphyses of the long bones of the human hand and foot","volume":"41","author":"Roche AF","year":"1959","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_1_32_2","first-page":"534\u2013543","volume-title":"Diagnosis and management of lameness in the horse","author":"Douglas J","year":"2003"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb00493.x"},{"key":"e_1_2_1_34_2","first-page":"881","article-title":"Ueber Vorkommen und Bedeutung epiphys\u00e4rer Ern\u00e4hrungsunterbrechungen beim Menschen","volume":"69","author":"Axhausen G","year":"1922","journal-title":"M\u00fcnchener Medizinische Wochenschrift"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000147004"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-002-0412-0"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.20375","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.20375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:18:41Z","timestamp":1707783521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.20375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,5]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/jor.20375"],"URL":"https:\/\/doi.org\/10.1002\/jor.20375","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,5]]},"assertion":[{"value":"2006-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}