{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:34:57Z","timestamp":1789443297326,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,4,2]],"date-time":"2007-04-02T00:00:00Z","timestamp":1175472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metal\u2010on\u2010metal articulations were reintroduced to reduce polyethylene particle\u2010induced osteolysis. Elevated serum metal levels have been detected at short\u2010 and intermediate\u2010term follow\u2010up. There is little knowledge about long\u2010term effects of increased ionic metal generation. Our study was undertaken to provide information about long\u2010term survival, clinical outcome, radiographic appearance, and serum metal concentrations after a minimum 10 years follow\u2010up with a metal\u2010on\u2010metal hip prosthesis: 105 cementless primary total hip prostheses with metal\u2010on\u2010metal articulating surfaces were implanted in 98 patients with a mean age of 56 years. Clinical data, radiographs, and blood samples were obtained at a follow\u2010up visit 10 years after implantation. Serum cobalt and chromium levels were determined with use of atomic absorption spectrometry. General laboratory analyses included a full blood count and kidney function parameters. The Harris score was 92 points and the UCLA score 6 points after 10 years. Small osteolytic lesions and radiolucent lines were found in Gruen's zones 1, 7, 8, and 14. The probability of survival was 98.6%. The median serum cobalt concentration of the 22 patients with their hip replacement as the only source of cobalt was 0.75 \u00b5g\/L (range, 0.3\u201350.1 \u00b5g\/L). No patient was diagnosed with renal insufficiency during the study period. Five patients were diagnosed with a malignancy between surgery and the follow\u2010up. We do not have evidence of an increased rate of primary malignancies nor could we detect renal failure in our study group. Serum metal levels did not differ from short\u2010 and intermediate term follow\u2010up values. \u00a9 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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