{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:41:50Z","timestamp":1791304910121,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T00:00:00Z","timestamp":1182988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Secreted frizzled\u2010related protein\u20103 (sFRP3) antagonizes ligands that promote new bone formation in adult tissues. We examined whether variation in the <jats:italic>FRZB<\/jats:italic> gene that encodes sFRP3 is associated with development of osteolysis or heterotopic ossification (HO) after total hip arthroplasty (THA). Genomic DNA was extracted from 609 subjects (osteolysis group <jats:italic>n<\/jats:italic>\u2009=\u2009268) at a mean of 11 years following cemented THA for idiopathic osteoarthritis and genotyped for the <jats:italic>FRZB<\/jats:italic> Arg200Trp and Arg324Gly polymorphisms. The Brooker classification was used to assess HO following primary THA in 563 of the subjects. The carriage rate of the <jats:italic>FRZB<\/jats:italic> 200Trp allele was 14.2% in subjects with osteolysis versus 21.0% in controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.041). The carriage rate of this allele was 21.7% in subjects with HO (<jats:italic>n<\/jats:italic>\u2009=\u2009299) versus 12.0% in those without HO (<jats:italic>p<\/jats:italic>\u2009=\u20090.063). The odds ratio for osteolysis with carriage of <jats:italic>FRZB<\/jats:italic> 200Trp was 0.62 (95% CI 0.38 to 0.99; <jats:italic>p<\/jats:italic>\u2009=\u20090.049) and for HO was 1.64 (1.05 to 2.54; <jats:italic>p<\/jats:italic>\u2009=\u20090.028), after adjustment for the effects of other risk factors associated with the development of osteolysis or HO. Variants in the <jats:italic>FRZB<\/jats:italic> 324 locus alone were not associated with osteolysis or HO. However, the most frequent haplotype (<jats:italic>FRZB<\/jats:italic> 200Arg:324Arg) was associated with osteolysis (OR 1.50, 95% CI 1.09 to 2.07; <jats:italic>p<\/jats:italic>\u2009=\u20090.014). Our data suggest that the <jats:italic>FRZB<\/jats:italic> Arg200Trp locus may be a marker for pro\u2010osteoblastic activity after THA. Carriage of the <jats:italic>FRZB<\/jats:italic> 200Trp allele is associated with a \u201cpositive\u201d bone balance phenotype (osteolysis \u2212: HO+). \u00a9 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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