{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:16:10Z","timestamp":1791018970957,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T00:00:00Z","timestamp":1207785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A feedback mechanism between different tissues in a growing bone is thought to determine the bone's morphogenesis. Cartilage growth strains the surrounding tissues, eliciting alterations of its matrix, which in turn, creates anisotropic stresses, guiding directionality of cartilage growth. The purpose of this study was to evaluate this hypothesis by determining whether collagen fiber directions in the perichondrium and periosteum align with the preferential directions of long bone growth. Tibiotarsi from chicken embryos across developmental stages were scanned using optical projection tomography (OPT) to assess preferential directions of growth at characteristic sites in perichondrium and periosteum. Quantified morphometric data were compared with two\u2010photon laser\u2010scanning microscopy images of the three\u2010dimensional collagen network in these fibrous tissues. The diaphyseal periosteum contained longitudinally oriented collagen fibers that aligned with the preferential growth direction. Longitudinal growth at both metaphyses was twice the circumferential growth. This concurred with well\u2010developed circumferential fibers, which covered and were partly interwoven with a dominant network of longitudinally oriented fibers in the outer layer of the perichondrium\/periosteum at the metaphysis. Toward both articulations, the collagen network of the epiphyseal surface was randomly oriented, and growth was approximately biaxial. These findings support the hypothesis that the anisotropic architecture of the collagen network, detected in periosteum and perichondrium, concurs with the assessed growth directions. \u00a9 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 26:1263\u20131268, 2008<\/jats:p>","DOI":"10.1002\/jor.20586","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T19:55:31Z","timestamp":1207857331000},"page":"1263-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Collagen orientation in periosteum and perichondrium is aligned with preferential directions of tissue growth"],"prefix":"10.1002","volume":"26","author":[{"given":"Jasper","family":"Foolen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrinus","family":"van Donkelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Nowlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Huiskes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,10]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"359","volume-title":"Cell behaviour","author":"Wolpert L","year":"1981"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050370102"},{"issue":"3","key":"e_1_2_1_4_2","first-page":"393","article-title":"The development of the perichondrium in the avian ulna","volume":"181","author":"Rooney P","year":"1992","journal-title":"J Anat"},{"key":"e_1_2_1_5_2","unstructured":"RooneyP.1984.The cellular basis of cartilage morphogenesis in embryonic chick limbs. PhD thesis University of London."},{"key":"e_1_2_1_6_2","first-page":"11","article-title":"Longitudinal overgrowth of chicken radius","volume":"112","author":"Crilly RG","year":"1972","journal-title":"J Anat"},{"key":"e_1_2_1_7_2","volume-title":"Pediatric orthopedic deformities, basic science, diagnosis, and treatment","author":"Shapiro F","year":"2001"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00003086-198811000-00036","article-title":"The effect of partial periosteal division on growth of the long bones. An experimental study in rabbits","volume":"236","author":"Dimitriou CG","year":"1988","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00911-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090102"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(01)00050-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1062"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1247\/csf.27.139"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4618"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.01.005"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2000.00226.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20050"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820110113"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100140120"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.128"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-006-0354-z"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001950404"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068206"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2006.01.013"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00035-0"},{"key":"e_1_2_1_26_2","unstructured":"ChenJC ZhaoB LongakerMT et al.2007.Periosteal biaxial residual stresses and strains during chick embryonic bone growth. 53rd annual meeting of the Orthopaedic Research Society San Diego; abstract number 1333."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198264030-00010"},{"key":"e_1_2_1_28_2","first-page":"173","article-title":"Collagen\u2010fibers in the periosteum of a long bone","volume":"21","author":"Dejonge P","year":"1983","journal-title":"Acta Morphol Neerlando\u2010Scand"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-8166(96)80031-0"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001140310"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.20136"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00013-7"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.79.1.67"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200203069"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(02)00233-6"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1992525"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2006.00314.x"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2003.08.004"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1865187"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.05.006"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.20586","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.20586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:40:18Z","timestamp":1700005218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.20586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,10]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1002\/jor.20586"],"URL":"https:\/\/doi.org\/10.1002\/jor.20586","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,10]]},"assertion":[{"value":"2007-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}