{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:56:36Z","timestamp":1758992196570},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T00:00:00Z","timestamp":1216166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alternative bearing surfaces for total hip arthroplasty, such as metal\u2010on\u2010metal and ceramic\u2010on\u2010ceramic, offer the potential to reduce mechanical wear and osteolysis. In the short and medium term, the second generation of metal\u2010on\u2010metal bearings demonstrated high systemic metal ion levels, whereas ceramic\u2010on\u2010ceramic bearings showed the lowest ones. We aimed to verify whether the long\u2010term ion release in metal\u2010on\u2010metal subjects was still relevant at a median 10\u2010year follow\u2010up, and whether a fretting process at the modular junctions occurred in ceramic\u2010on\u2010ceramic patients and induced an ion dissemination. Serum levels were measured in 32 patients with alumina\u2010on\u2010alumina implants (group A), in 16 subjects with metal\u2010on\u2010metal implants (group B), and in 47 healthy subjects (group C). Group B results were compared with medium\u2010term findings. Cobalt and chromium levels were significantly higher in metal\u2010on\u2010metal implants than in ceramic\u2010on\u2010ceramic ones and controls. Nevertheless, ion levels showed a tendency to decrease in comparison with medium\u2010term content. In ceramic\u2010on\u2010ceramic implants, ion values were not significantly different from controls. Both in groups A and B, aluminum and titanium release were not significantly different from controls. In conclusion, negligible serum metal ion content was revealed in ceramic\u2010on\u2010ceramic patients. On the contrary, due to the higher ion release, metal\u2010on\u2010metal coupling must be prudently considered, especially in young patients, in order to obtain definitive conclusions. \u00a9 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res<\/jats:p>","DOI":"10.1002\/jor.20701","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T17:06:25Z","timestamp":1216227985000},"page":"1569-1576","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Serum ion levels after ceramic\u2010on\u2010ceramic and metal\u2010on\u2010metal total hip arthroplasty: 8\u2010year minimum 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