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With a rat ACL rotating injury model, we found that levels of IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 were significantly higher in synovial fluids after ACL injury. MMP\u20102 activity and global MMP activity in synovial fluids also increased significantly in a time\u2010dependent manner. Ex vivo studies showed that all tissues contributed to the elevation of MMP\u20102 in synovial fluids, especially synovium and the injured ACL. We concluded that although the regular wound\u2010healing mechanism also occurs after ACL injury, accumulation of MMP activity in the synovial fluids, due to all of the intraarticular tissues, may be at least one of the important reasons why an injured ACL cannot be repaired. \u00a9 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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