{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:15:55Z","timestamp":1780053355468,"version":"3.54.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T00:00:00Z","timestamp":1224028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rotator cuff tears are disabling conditions that result in changes in joint loading and functional deficiencies. Clinically, damage to the long\u2010head of the biceps tendon has been found in conjunction with rotator cuff tears, and this damage is thought to increase with increasing tear size. Despite its importance, controversy exists regarding the optimal treatment for the biceps. An animal model of this condition would allow for controlled studies to investigate the etiology of this problem and potential treatment strategies. We created rotator cuff tears in the rat model by detaching single (supraspinatus) and multiple (supraspinatus\u2009+\u2009infraspinatus or supraspinatus\u2009+\u2009subscapularis) rotator cuff tendons and measured the mechanical properties along the length of the long\u2010head of the biceps tendon 4 and 8 weeks following injury. Cross\u2010sectional area of the biceps was increased in the presence of a single rotator cuff tendon tear (by \u223c150%), with a greater increase in the presence of a multiple rotator cuff tendon tear (by up to 220%). Modulus values decreased as much as 43 and 56% with one and two tendon tears, respectively. Also, multiple tendon tear conditions involving the infraspinatus in addition to the supraspinatus affected the biceps tendon more than those involving the subscapularis and supraspinatus. Finally, biceps tendon mechanical properties worsened over time in multiple rotator cuff tendon tears. Therefore, the rat model correlates well with clinical findings of biceps tendon pathology in the presence of rotator cuff tears, and can be used to evaluate etiology and treatment modalities. \u00a9 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:416\u2013420, 2009<\/jats:p>","DOI":"10.1002\/jor.20770","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T23:31:23Z","timestamp":1224113483000},"page":"416-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Mechanical properties of the long\u2010head of the biceps tendon are altered in the presence of rotator cuff tears in a rat model"],"prefix":"10.1002","volume":"27","author":[{"given":"Cathryn D.","family":"Peltz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Getz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Soslowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1009","volume-title":"The shoulder","author":"Burkhead WZ","year":"1998"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20668"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199274010-00008"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000170052.84544.34"},{"issue":"2","key":"e_1_2_1_6_2","first-page":"429","article-title":"Morphology of the torn rotator cuff","volume":"186","author":"Itoi E","year":"1995","journal-title":"J Anat"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-2746(96)80070-X"},{"key":"e_1_2_1_8_2","unstructured":"PerrySM GetzCL SoslowskyLJ.2007.The effect of tear size on the mechanical properties of the remaining intact tendons in a rat rotator cuff model. Transactions of the Orthopaedic Research Society San Diego; p1163."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.09.019"},{"key":"e_1_2_1_10_2","unstructured":"FavataM.2006.Scarless healing in the fetus: implications and strategies for postnatal tendon repair. Bioengineering PhD Thesis. Philadelphia: University of Pennsylvania; p216."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1114\/1.1509765"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mse.2000.108386"},{"key":"e_1_2_1_13_2","unstructured":"PerrySM ReidichBJ PeltzCD et al.2006.Rat ambulation alterations due to supraspinatus tendon detachment. ASME Summer Bioengineering Conference Amelia Island Plantation."},{"key":"e_1_2_1_14_2","unstructured":"PerrySM GetzCL SoslowskyLJ.2007.The effect of tear size on the mechanical properties of the remaining intact tendons in a rat rotator cuff model. Transactions of the Orthopaedic Research Socity San Diego; p1163."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B8.19278"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.20770","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.20770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T12:53:27Z","timestamp":1699966407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.20770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,9]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1002\/jor.20770"],"URL":"https:\/\/doi.org\/10.1002\/jor.20770","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,9]]},"assertion":[{"value":"2008-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}