{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:46:39Z","timestamp":1791143199334,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T00:00:00Z","timestamp":1247529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Daily low\u2010amplitude, high\u2010frequency whole\u2010body vibration (WBV) treatment can increase bone formation rates and bone volume in rodents. Its effects vary, however, with vibration characteristics and study design, and effects on 3D bone microstructure of ovariectomized animals over time have not been documented. Our goal was to determine the effects of WBV on tibial bone of ovariectomized, mature rats over time using an in vivo micro\u2010CT scanner. Adult rats were divided into: ovariectomy (OVX) (n\u2009=\u20098), SHAM\u2010OVX (<jats:italic>n<\/jats:italic>\u2009=\u20098), OVX and WBV treatment (<jats:italic>n<\/jats:italic>\u2009=\u20097). Eight weeks after OVX, rats in the vibration group were placed on a vibrating platform for 20\u2009min at 0.3\u2009g and 90 Hertz. This was done 5 days a week for six weeks, twice a day. Zero, 8, 10, 12 and 14 weeks after OVX, in vivo micro\u2010CT scans were made (vivaCT 40, Scanco Medical AG) of the proximal and diaphyseal tibia. After sacrifice, all tibiae were dissected and tested in three\u2010point bending. In the metaphysis between 8 to 12 weeks after OVX, WBV treatment did not alter structural parameters compared to the OVX group and both groups continued to show deterioration of bone structure. In the epiphysis, structural parameters were not altered. WBV also did not affect cortical bone and its bending properties. To summarize, no substantial effects of 6 weeks of low\u2010magnitude, high\u2010frequency vibration treatment on tibial bone microstructure and strength in ovariectomized rats were found. \u00a9 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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