{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T17:22:44Z","timestamp":1773595364768,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T00:00:00Z","timestamp":1262822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reparative strategies for the treatment of injuries to tendons, including those of the rotator cuff of the shoulder, need to address the formation of the cartilage which serves as the attachment apparatus to bone and which forms at regions undergoing compressive loading. Moreover, recent work indicates that cells employed for rotator cuff repair may need to synthesize a lubricating glycoprotein, lubricin, which has recently been found to play a role in tendon tribology. The objective of the present study was to investigate the chondrogenic differentiation and lubricin expression of caprine infraspinatus tendon cells in monolayer and three\u2010dimensional culture, and to compare the behavior with bone marrow\u2010derived mesenchymal stem cells (MSCs). The results demonstrated that while tendon cells in various media, including chondrogenic medium, expressed lubricin, virtually none of the MSCs synthesized this important lubricating molecule. Also of interest was that the cartilage formation capacity of the tendon cells grown in pellet culture in chondrogenic medium was comparable with MSCs. These data inform the use of tendon cells for rotator cuff repair, including for fibrocartilaginous zones. \u00a9 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:716\u2013725, 2010<\/jats:p>","DOI":"10.1002\/jor.21053","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T18:16:31Z","timestamp":1262888191000},"page":"716-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Chondrogenic differentiation and lubricin expression of caprine infraspinatus tendon cells"],"prefix":"10.1002","volume":"28","author":[{"given":"Tadanao","family":"Funakoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron","family":"Spector","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197052010-00001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1998.19340481.x"},{"issue":"3","key":"e_1_2_6_4_2","first-page":"625","article-title":"Fibrocartilage associated with human tendons and their pulleys","volume":"187","author":"Benjamin M","year":"1995","journal-title":"J Anat"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008207909152351"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90127-I"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.4.474"},{"key":"e_1_2_6_8_2","first-page":"30","article-title":"Uber Ursprung und Insertion der Skelettmuskeln","volume":"68","author":"Dolgo\u2010Saburoff B","year":"1929","journal-title":"Anat Anz"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100180405"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711390403"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711690315"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21212"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-8-16"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1630"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1263\/jbb.100.418"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00627"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008200600846754"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20239"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00051-X"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(00)90011-1"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/107632701753337762"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2002.5561"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3858"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CBTO.0000010395.51944.2a"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.05.004"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.2144\/000112009"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100402"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2005.03.008.1100230621"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00066-1"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32522"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20344"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1182\/blood.V78.2.304.304","article-title":"Expression of alpha\u2010smooth muscle actin in murine bone marrow stromal cells","volume":"78","author":"Peled A","year":"1991","journal-title":"Blood"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90306-5"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20986"},{"key":"e_1_2_6_35_2","first-page":"21","article-title":"Alpha\u2010smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing","volume":"63","author":"Darby I","year":"1990","journal-title":"Lab Invest"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.12408.x"},{"key":"e_1_2_6_37_2","first-page":"144","article-title":"Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulation","volume":"63","author":"Sappino AP","year":"1990","journal-title":"Lab Invest"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(00)00081-4"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100180511"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100170105"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100140210"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200010000-00004"},{"key":"e_1_2_6_43_2","first-page":"3390","article-title":"Generation of neo\u2010tendon using synthetic polymers seeded with tenocytes","volume":"26","author":"Cao Y","year":"1994","journal-title":"Transplant Proc"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200107)56:1<31::AID-JBM1065>3.0.CO;2-N"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200107)56:1<40::AID-JBM1066>3.0.CO;2-I"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546504272689"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.1999.5.267"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1089\/10763270360696969"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(76)90299-8"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-004-0694-9"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v013a04"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.1.103"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.9.4219"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.21053","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.21053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.21053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T22:56:30Z","timestamp":1697669790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.21053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,14]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/jor.21053"],"URL":"https:\/\/doi.org\/10.1002\/jor.21053","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,14]]},"assertion":[{"value":"2008-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}