{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:22:17Z","timestamp":1778710937938,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T00:00:00Z","timestamp":1262822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the effects of locally and systemically administered alendronate on wear debris\u2010induced osteolysis in vivo. Endotoxin\u2010free titanium particles were injected into rabbit femurs, prior to insertion of a nonweight\u2010bearing polymethylmethacrylate plug into the distal femur canal. Then the particles were repeatedly injected into the knee 2, 4, and 6 weeks after the implantation. Alendronate was incorporated at three different concentrations (0.1, 0.5, and 1.0\u2009wt %) into bone cement for local delivery. For systemic delivery, alendronate was subcutaneously injected (1.0\u2009mg\/kg\/week) 1\u2009week after the implantation and then once a week until sacrifice. Eight weeks postoperatively, there was significant evidence of osteolysis surrounding the plug in the control group compared with markedly blocked osteolysis in the 0.5\u2009wt % and the 1.0\u2009wt % groups, and the systemic group. There was a concentration\u2010dependent effect of alendronate\u2010loaded bone cement on the improvement of peri\u2010prosthetic bone stock. Notably, no significant differences were found between the 0.5\u2009wt % and the systemic group in peri\u2010prosthetic bone stock and implant fixation. Collectively, although the biological efficacy after the systemic delivery of alendronate was slightly higher than that in the local treatment groups, alendronate\u2010loaded bone cement may be therapeutically effective in inhibiting titanium particle\u2010induced osteolysis in vivo. \u00a9 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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