{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:03:09Z","timestamp":1792717389707,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,10,11]],"date-time":"2010-10-11T00:00:00Z","timestamp":1286755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High cholesterol represents a significant healthcare problem. Clinical studies have linked hypercholesterolemia to Achilles tendon xanthomas and rotator cuff tears, and research in other systems indicates detrimental effects of high cholesterol; however, understanding of its impact on tendon properties and healing is limited. We hypothesized that tendons from aging hypercholesterolemic (APOE) mice would exhibit inferior baseline and healing mechanical properties compared to controls, while younger, but mature mice would be no different. Surprisingly, tensile testing of patellar tendons from 14\u2010week\u2010old APOE mice receiving a unilateral full\u2010thickness central defect resulted in normalized (injured:sham) cross\u2010sectional areas closer to baseline (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) compared to controls. Uninjured data from 10\u2010month\u2010old APOE mice showed a decrease in elastic modulus (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), indicating a detrimental effect of hypercholesterolemia on tendon properties in this model. These results could benefit patients through knowledge that high cholesterol could increase the likelihood of tendon tears. Furthermore, knowledge that tendon tears are indicative of high cholesterol could provide orthopedic clinicians with an additional preventive treatment opportunity for patients with undiagnosed hypercholesterolemia. \u00a9 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:380\u2013383, 2011<\/jats:p>","DOI":"10.1002\/jor.21255","type":"journal-article","created":{"date-parts":[[2010,10,11]],"date-time":"2010-10-11T19:46:03Z","timestamp":1286826363000},"page":"380-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Cumulative effects of hypercholesterolemia on tendon biomechanics in a mouse model"],"prefix":"10.1002","volume":"29","author":[{"given":"David P.","family":"Beason","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Kuntz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Bassora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Soslowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","volume-title":"The burden of musculoskeletal diseases in the United States","author":"Andersson GBJ","year":"2008"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1058-2746(99)90148-9"},{"key":"e_1_2_6_4_2","unstructured":"National Center for Health Statistics: Health United States 2008."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01484.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000022600.61391.A5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.040766"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00075-5"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004020050410"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.1.44"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1151-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.18.1876"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.11.009"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0463com"},{"key":"e_1_2_6_15_2","unstructured":"FavataM.2006. Scarless Healing in the Fetus: Implications and Strategies for Postnatal Tendon Repair (PhD Dissertation). Philadelphia: University of Pennsylvania."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(94)90281-X"},{"key":"e_1_2_6_17_2","first-page":"623","volume-title":"Orthopaedic basic science","author":"Lieber RL","year":"1994"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.21255","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.21255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T11:33:05Z","timestamp":1696851185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.21255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,11]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/jor.21255"],"URL":"https:\/\/doi.org\/10.1002\/jor.21255","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,11]]},"assertion":[{"value":"2009-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}