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Fresh intact porcine knees were preloaded and impacted at 294\u2009J via a drop track. Osteochondral cores were obtained from the medial and lateral aspects of the femoral condyles and tibial plateau. Chondrocyte viability was assessed at days 0, 3, and 5 postimpact in sham, impacted nonfractured, and impacted fractured joints. Total matrix metalloproteinase (MMP) activity, aggrecanase (ADAMTS\u20104) activity, and sulfated glycosaminoglycan (S\u2010GAG) release were measured in culture media from days 3 and 5 posttrauma. No differences were observed in chondrocyte viability of impacted nonfractured joints (95.9\u2009\u00b1\u20096.9%) when compared to sham joints (93.8\u2009\u00b1\u20097.7%). In impacted fractured joints, viability of the fractured edge was 40.5\u2009\u00b1\u200927.6% and significantly lower than all other sites, including cartilage adjacent to the fractured edge (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). MMP and aggrecanase activity and S\u2010GAG release were significantly increased in specimens from the fractured edge. This study showed that joint impact resulting in articular fracture significantly decreased chondrocyte viability, increased production of MMPs and aggrecanases, and enhanced S\u2010GAG release, whereas the same level of impact without fracture did not cause such changes. \u00a9 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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