{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T04:16:13Z","timestamp":1778991373459,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T00:00:00Z","timestamp":1291334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteopetrotic patients possess a genetic condition that leads to a deficiency in osteoclast number or function. Patients have a high bone density and suffer from an increased risk of fracture. The lack of normal osteoclast activity has the potential to impede repair by complicating orthopedic fixation and\/or by affecting the biology of fracture healing. The naturally occurring <jats:italic>incisors absent (ia\/ia)<\/jats:italic> rat was adopted as a rodent model of congenital osteopetrosis. A detailed phenotypic analysis of the <jats:italic>ia\/ia<\/jats:italic> rat indicated that some functional recovery occurred between 7 and 9 weeks. Consequently a fracture repair study was undertaken using 5\u2010week\u2010old rats. Closed femoral fractures were generated in <jats:italic>ia\/ia<\/jats:italic> rats and control <jats:italic>ia\/+<\/jats:italic> and <jats:italic>+\/+<\/jats:italic> rats using an Einhorn apparatus. Fracture healing was examined radiologically and histologically at 1\u20133 weeks. No difference was seen in bridging between <jats:italic>ia\/ia<\/jats:italic> and control rats at any time point. The <jats:italic>ia\/ia<\/jats:italic> rats showed no delay in cartilage removal but showed a significant delay in hard callus remodeling. This is consistent with an essential role for osteoclasts in only the latter stages of endochondral bone repair. This delay in hard callus remodeling was offset by an increase in moment of inertia. \u00a9 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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