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The surface modification of allogenic bone substitutes (dehydrated human femoral head) was achieved in a double\u2010conductive low\u2010pressure gasplasma reactor (Ar<jats:sub>2<\/jats:sub>\/O<jats:sub>2<\/jats:sub>, 13.65\u2009MHz, 1,000\u2009W, 5\u2009Pa). The modified bone substitutes (<jats:italic>n<\/jats:italic>\u2009=\u200910) as well as untreated bone substitutes serving as controls (<jats:italic>n<\/jats:italic>\u2009=\u200910) were placed into the dorsal skinfold chamber of female balb\/c mice (<jats:italic>n<\/jats:italic>\u2009=\u200910). Dynamic assessment of microcirculatory parameters was performed using intravital fluorescence microscopy during an implantation period of 10 days. The angiogenic response was found markedly accelerated in gasplasma\u2010treated bone. Compared to untreated implants, the gasplasma\u2010activated bone substitutes showed significantly higher microvascular density on days 5 and 10. The quantification of the microvascular diameters, red blood cell velocity, and microvascular permeability displayed stable perfusion and vascular integrity of the newly developed blood vessels throughout the 10\u2010day observation period. The surface activation via cold low\u2010pressure glow discharge gasplasma supports the vascular integration of allogenic bone by earlier induction of the angiogenesis. \u00a9 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. 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