{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:42:12Z","timestamp":1773240132601,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T00:00:00Z","timestamp":1298505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Among the predisposing factors to osteoarthritis (OA), a frequent destructive joint disease, is the complex genetic heritage including the interleukin\u20101 family members like the IL1\u03b2 (IL1B) and the IL1 receptor antagonist (IL1RN) genes. The aim of this study was to investigate allelic and genotypic frequencies of the IL1B gene single nucleotide polymorphism (SNP) at \u2212511(G&gt;A) and the variable number tandem repeat (VNTR) in the IL1RN gene in a Croatian Caucasian population of hip OA (HOA) cases and healthy controls. A total of 259 HOA patients with total hip replacement (THR) and 518 healthy blood donors as controls were genotyped for IL1B gene SNP \u2212511(G&gt;A) and the VNTR in the IL1RN gene associated with HOA. The genotype G\/A (1\/2) at IL1B was significantly associated with the protection of the HOA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.036, OR\u2009=\u20090.72, 95% CI\u2009=\u20090.52\u20130.99). The genotype G\/G (1\/1) had only a trend towards the susceptibility (<jats:italic>p<\/jats:italic>\u2009=\u20090.053, OR\u2009=\u20091.35, 95% CI\u2009=\u20090.98\u20131.86) to disease. None of the haplotypes IL1B \u2212511(G&gt;A) and IL1RN (VNTR) were found associated with the HOA. The haplotype 1\u20132 at these loci had only a trend to susceptibility (<jats:italic>p<\/jats:italic>\u2009=\u20090.065). Haplotype 1\u20133 had a significant male bias in diseased. Furthermore, genotype comprising 2\u20131\/2\u20132 haplotypes was found significantly associated with predisposition to HOA (<jats:italic>p<\/jats:italic>\u2009=\u20090.027, OR\u2009=\u20092.23, 95% CI\u2009=\u20091.03\u20134.88), whereas genotype 1\u20131\/2\u20132 with protection to disease (<jats:italic>p<\/jats:italic>\u2009=\u20090.028, OR\u2009=\u20090.65, 95% CI\u2009=\u20090.43\u20130.97). Our findings suggest that HOA in Croatian population might have a different genetic risk regarding the IL1 locus than has been reported for other Caucasian populations previously. \u00a9 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1137\u20131144, 2011<\/jats:p>","DOI":"10.1002\/jor.21378","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T15:30:43Z","timestamp":1298734243000},"page":"1137-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hip osteoarthritis susceptibility is associated with IL1B \u2212511(G&gt;A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian caucasian population"],"prefix":"10.1002","volume":"29","author":[{"given":"Zdravko","family":"Jotanovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfrey E.","family":"Etokebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radovan","family":"Mihelic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marikken","family":"Heiland K\u00e5rvatn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biserka","family":"Mulac\u2010Jericevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Tijanic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Balen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branko","family":"Sestan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zlatko","family":"Dembic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2005.02.005"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"s201","DOI":"10.3928\/0147-7447-20050202-04","article-title":"Epidemiology of osteoarthritis","volume":"28","author":"D'Ambrosia RD","year":"2005","journal-title":"Orthopedics"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(03)00067-8"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.79B4.7437"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.7.583"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8593"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7270.1179"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200103000-00004"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(03)00071-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.8.955"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200848"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10412"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.014498"},{"key":"e_1_2_6_15_2","first-page":"210","article-title":"Genetic aspects of osteoarthritis","volume":"87","author":"Lally EV","year":"2004","journal-title":"Med Health (Rhode Island)"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.024661"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(03)00161-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.09.005"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2008.04.008"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10260"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2417::AID-ANR7>3.0.CO;2-R"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20121"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20813"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.03.022"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2554"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340502"},{"issue":"12","key":"e_1_2_6_27_2","first-page":"2473","article-title":"WOMAC: a 20\u2010year experiential review of a patient\u2010centered self\u2010reported health status questionnaire","volume":"29","author":"Bellamy N","year":"2002","journal-title":"J Rheumatol"},{"issue":"24","key":"e_1_2_6_28_2","first-page":"1950","article-title":"Total hip replacement. 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