{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:33:25Z","timestamp":1783953205082,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T00:00:00Z","timestamp":1302480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemokines produced by synoviocytes of the subacromial bursa are up\u2010regulated in subacromial bursitis and rotator cuff disease. We hypothesized that SDF\u20101\u03b1 production in bursal synoviocytes may be induced by local cytokines such as interleukin IL\u20101\u03b2 and IL\u20106. Subacromial bursa specimens were obtained from patients undergoing shoulder surgery. Bursal specimens were stained with anti\u2010human antibodies to IL\u20101, IL\u20106, and SDF\u20101\u03b1 by immunohistochemistry and compared to normal and rheumatoid controls. Bursal cells were also isolated from specimens and cultured. Early passaged cells were then treated with cytokines (IL\u20101\u03b2 and IL\u20106) and SDF\u20101\u03b1 expression was measured by ELISA and RT\u2010PCR. SDF\u20101\u03b1, IL\u20101\u03b2, and IL\u20106 were expressed at high levels in bursitis specimens from human subacromial bursa compared to normal controls. In cultured bursal synoviocytes, there was a dose\u2010dependent increase in SDF\u20101\u03b1 production in the supernatants of cells treated with IL\u20101\u03b2. SDF\u20101\u03b1 mRNA expression was also increased in bursal cells treated with IL\u20101\u03b2. IL\u20106 caused a minimal but not statistically significant increase in SDF\u20101\u03b1 expression. SDF\u20101\u03b1, IL\u20101\u03b2, and IL\u20106 are expressed in the inflamed human subacromial bursal tissues in patients with subacromial bursitis. In cultured bursal synoviocytes, SDF\u20101\u03b1 gene expression and protein production are stimulated by IL\u20101\u03b2. IL\u20101\u03b2 produced by bursal syvoviocytes and inflammatory cells in the human subacromial bursa is an important signal in the inflammatory response that occurs in subacromial bursitis and rotator cuff disease. \u00a9 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. 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