{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:59:37Z","timestamp":1783961977291,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T00:00:00Z","timestamp":1309132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate an association between steroid\u2010induced femoral head osteonecrosis (FHON) and functional vascular endothelial growth factor (VEGF) gene (\u22122578A\/C, \u22121154A\/G, \u2212634C\/G, and +405C\/G) polymorphisms polymerase chain reaction\u2010restriction fragment length polymorphism genotyping was performed in 160 patients (86 idiopathic FHON and 74 steroid\u2010induced FHON) and 160 gender\u2010 and age\u2010matched controls. The steroid\u2010induced subgroup had a significantly lower prevalence of \u22121154A allele (7.4% vs. 18.1%, odds ratio (OR)\u2009=\u20090.363) and genotype carrying \u22121154A (14.9% vs. 32.5%, OR\u2009=\u20090.333 in a recessive model) than controls. In a dominant model, the frequency of genotype carrying +405G (74.3% vs. 84.4%, OR\u2009=\u20090.492) was significantly lower in steroid\u2010induced FHON than in controls. The distribution of haplotypes was significantly different between controls and FHON patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.00011). Especially, when haplotypes were classified into high (CGCG and AAGG) or low (CGGC and AGGC) VEGF inducing haplotypes, patients with steroid\u2010induced FHON had a significantly lower prevalence of high inducing haplotypes (7.4% vs. 15.9%, OR\u2009=\u20090.424) and a significantly higher prevalence of low inducing haplotypes (4.7% vs. 0.6%, OR\u2009=\u20097.894) than controls. Low inducing VEGF haplotypes may confer an increased risk and high inducing haplotypes have a protective effect for the development of steroid\u2010induced FHON in Korea. \u00a9 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:21\u201327, 2012<\/jats:p>","DOI":"10.1002\/jor.21492","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T12:43:36Z","timestamp":1309437816000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Vascular endothelial growth factor polymorphisms in patients with steroid\u2010induced femoral head osteonecrosis"],"prefix":"10.1002","volume":"30","author":[{"given":"Yun Jong","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun 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