{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:14:25Z","timestamp":1773724465411,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:00:00Z","timestamp":1318896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The most common histological finding in carpal tunnel syndrome (CTS) is non\u2010inflammatory fibrosis and thickening of the subsynovial connective tissue (SSCT) in the tunnel. While the cause of SSCT fibrosis and the relationship of SSCT fibrosis and CTS are unknown, one hypothesis is that SSCT injury causes fibrosis, and that the fibrosis then leads to CTS. We investigated the sensitivity of the SSCT to injuries. Two types of surgical interventions were performed in a rabbit model: A skin incision with tendon laceration and SSCT stretching sufficient to damage the SSCT, and skin incision alone. Twelve weeks after surgery, the rabbit carpal tunnel tissues were studied with immunochemistry for TGF\u2010\u03b2 receptors 1, 2, and 3, collagen III, and collagen VI. All TGF\u2010\u03b2 receptors were expressed. The percentages of the TGF\u2010\u03b2 receptors' expressions were less in the control SSCT fibroblasts than in the fibroblasts from rabbits with surgical interventions. The surgical interventions did not result in any alteration of collagen III expression. However, both surgical interventions resulted in a significant decrease in collagen VI expression compared to the control group. The two surgical interventions achieved similar expression of TGF\u2010\u03b2 receptors and collagens. Our results provide evidence that the SSCT is sensitive to surgical interventions, even when these are modest. Since SSCT fibrosis is a hallmark of CTS, these data also suggest that such fibrosis could result from relatively minor trauma. \u00a9 2011 Orthopaedic Research Society. \u00a9 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:649\u2013654, 2012<\/jats:p>","DOI":"10.1002\/jor.21565","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T15:43:35Z","timestamp":1318952615000},"page":"649-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Subsynovial connective tissue is sensitive to surgical interventions in a rabbit model of carpal tunnel syndrome"],"prefix":"10.1002","volume":"30","author":[{"given":"Yu\u2010Long","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamami","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona L.","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Chikenji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M.","family":"Passe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Nan","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Amadio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"6","article-title":"Carpal tunnel syndrome","volume":"77","author":"Aroori S","year":"2008","journal-title":"Ulster Med J"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-009-1416-x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196648020-00001"},{"key":"e_1_2_6_5_2","first-page":"197","article-title":"Some histological changes in carpal tunnel contents and their biomechanical implications","volume":"26","author":"Armstrong TJ","year":"1984","journal-title":"J Occup Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(87)90020-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(92)90091-F"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(98)80009-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200407000-00014"},{"key":"e_1_2_6_10_2","volume-title":"New ideas in hand flexor tendon surgery. The sliding system. Vascularized flexor tendon transfers","author":"Guimberteau JC","year":"2001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2005.02.009"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000239593.55293.c7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(09)91053-X"},{"key":"e_1_2_6_14_2","unstructured":"MoriyaT ZhaoC ChaSS et al.2011. Tendon injury produces changes in SSCT and nerve physiology similar to carpal tunnel syndrome in an in vivo rabbit model. Hand. Published online 9\/10\/11."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21547"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880131211"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.1564"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.423"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2008.039719"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2007.06.004"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2003.12.006"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.276"},{"key":"e_1_2_6_23_2","first-page":"F105","article-title":"TGF\u2010beta receptor signaling","volume":"1333","author":"Derynck R","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2003.10.004"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2007.02.015"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2009.05.008"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290622"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67767-1"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200110000-00025"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70566-1"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225430.42531.c2"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1016\/S0021-9258(17)43189-9","article-title":"Type VI collagen. Studies on its localization, structure, and biosynthetic form with monoclonal antibodies","volume":"259","author":"Hessle H","year":"1984","journal-title":"J Biol Chem"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.5.1995"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(89)90103-1"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4051"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0328"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2009.08.001"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.06.017"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004020050417"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1159\/000267015"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470022"},{"key":"e_1_2_6_42_2","first-page":"425","article-title":"Scar formation and ligament healing","volume":"41","author":"Hildebrand KA","year":"1998","journal-title":"Can J Surg"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.10065"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1673"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.21565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.21565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.21565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:48:09Z","timestamp":1696873689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.21565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,18]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/jor.21565"],"URL":"https:\/\/doi.org\/10.1002\/jor.21565","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,18]]},"assertion":[{"value":"2011-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}