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Anti\u2010adhesive agents can be applied during surgery to prevent adhesion formation, whilst reportedly providing some reduction in friction during in vitro tendon\u2010bony pulley investigations. This bio\u2010tribological study evaluates whether application of these agents can improve the lubrication between the tendon and surrounding tissue, thus potentially reducing the risk of re\u2010rupturing the tendon at the repair site. The use of bovine synovial fluid (BSF) enabled an approximation of the in vivo lubrication regime, and subsequent comparison of the performance of three synthetic agents (50\u2009mg\/ml 5\u2010fluorouracil; 5\u2009mg\/ml hyaluronic acid; ADCON\u2013T\/N). Coefficient of friction data was recorded and then compared with the Stribeck curve. BSF generated a fluid film that separated the two surfaces, giving rise to optimal lubrication conditions. This efficient regime was also generated following application of each anti\u2010adhesion agent. The use of phosphate\u2010buffered saline solution in generating only a boundary lubrication regime highlighted the effectiveness of the agents in reducing friction. Hyaluronic acid (5\u2009mg\/ml) was marginally deemed the most effective anti\u2010adhesive agent at lubricating the tendon. Subsequently, it is concluded that the application of anti\u2010adhesive agents post\u2010surgery has secondary, tribological benefits that serve to reduce friction, and thus potentially the risk of failure, at the tendon repair site. \u00a9 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. 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