{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:14:47Z","timestamp":1770981287660,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accumulation of sub\u2010rupture fatigue damage has been implicated in the development of tendinopathy. We previously developed an in vivo model of damage accumulation using the rat patellar tendon. Our model allows us to control the input loading parameters to induce fatigue damage in the tendon. Despite this precise control, the resulting induced damage could vary among animals because of differences in size or strength among their patellar tendons. In this study, we used number of applied cycles and initial (day\u20100) parameters that are indicative of induced damage to assess the molecular response 7 days after fatigue loading. We hypothesized that day\u20100 hysteresis, elongation, and stiffness of the loading and unloading load\u2013displacement curves would be predictive of the 7\u2010day molecular response. Results showed correlations between the 7\u2010day molecular response and both day\u20100 elongation and unloading stiffness. Additionally, loading resulted in upregulation of several extracellular matrix genes that suggest adaptation; however, several of these genes (Col\u2010I, \u2010XII, MMP 2, and TIMP 3) shut down after a high level of damage was induced. We showed that evaluating the 7\u2010day molecular profile in light of day\u20100 elongation provides important insight that is lost from comparing number of fatigue loading cycles only. Our data showed that loading generally results in an adaptive response. However, the tendon's ability to effectively respond deteriorates as greater damage is induced. \u00a9 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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