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The purpose of this study was to examine the expression of ADAMTS\u20107 and ADAMTS\u201012 in the endplate cells isolated from patients with degenerative disc disease and to see whether they are associated with the pathological change of endplate. Sixty\u2010four degenerated lumbar endplate specimens were obtained from the patients with degenerative disc disease categorized as type Modic I or II in magnetic resonance imaging (MRI) and 12 nondegenerative specimens as control (vertebra burst fracture patients without degenerative change in MRI) during surgical procedures. The expression of ADAMTS\u20107 and ADAMTS\u201012 was examined by real\u2010time PCR and Western blotting. A statistically significant increase in mRNA expression of ADAMTS\u20107 and ADAMTS\u201012 was observed in the endplate cells in degenerative discs compared with nondegenerative discs. The corresponding protein levels of ADAMTS\u20107 and ADAMTS\u201012 had the same expression patterns. Moreover, ADAMTS\u20107 and ADAMTS\u201012 down\u2010regulated the expression of Col II, Sox9, and Col X the marker genes for chondrogenesis. Our results indicate that ADAMTS\u20107 and ADAMTS\u201012 appear to be potent negative regulators of endplate cartilage development. \u00a9 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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