{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:26:45Z","timestamp":1790994405429,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T00:00:00Z","timestamp":1338854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>NSAIDs are widely prescribed and used over the years to treat tendon injuries despite its well\u2010known long\u2010term side effects. In the last years several animal and human trials have shown that low\u2010level laser therapy (LLLT) presents modulatory effects on inflammatory markers, however the mechanisms involved are not fully understood. The aim of this study was to evaluate the short\u2010term effects of LLLT or sodium diclofenac treatments on biochemical markers and biomechanical properties of inflamed Achilles tendons. Wistar rats Achilles tendons (<jats:italic>n<\/jats:italic>\u2009=\u20096\/group) were injected with saline (control) or collagenase at peritendinous area of Achilles tendons. After 1\u2009h animals were treated with two different doses of LLLT (810\u2009nm, 1 and 3\u2009J) at the sites of the injections, or with intramuscular sodium diclofenac. Regarding biochemical analyses, LLLT significantly decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) COX\u20102, TNF\u2010\u03b1, MMP\u20103, MMP\u20109, and MMP\u201013 gene expression, as well as prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) production when compared to collagenase group. Interestingly, diclofenac treatment only decreased PGE<jats:sub>2<\/jats:sub> levels. Biomechanical properties were preserved in the laser\u2010treated groups when compared to collagenase and diclofenac groups. We conclude that LLLT was able to reduce tendon inflammation and to preserve tendon resistance and elasticity. \u00a9 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1945\u20131951, 2012<\/jats:p>","DOI":"10.1002\/jor.22156","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T17:48:23Z","timestamp":1338918503000},"page":"1945-1951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Low\u2010level laser therapy in collagenase\u2010induced Achilles tendinitis in rats: Analyses of biochemical and biomechanical aspects"],"prefix":"10.1002","volume":"30","author":[{"given":"Rodrigo Labat","family":"Marcos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto Cesar 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