{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:58:29Z","timestamp":1759777109001},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although post\u2010rehabilitation is routinely performed following flexor tendon repair, in some clinical scenarios post\u2010rehabilitation must be delayed. We investigated modification of the tendon surface using carbodiimide derivatized hyaluronic acid and lubricin (cd\u2010HA\u2010Lub) to maintain gliding function following flexor tendon repair with postoperative immobilization in a in vivo canine model. Flexor digitorum profundus tendons from the 2nd and 5th digits of one forepaw of six dogs were transected and repaired. One tendon in each paw was treated with cd\u2010HA\u2010Lub; the other repaired tendon was not treated. Following tendon repair, a forearm cast was applied to fully immobilize the operated forelimb for 10 days, after which the animals were euthanized. Digit normalized work of flexion (nWOF) and tendon gliding resistance were assessed. The nWOF of the FDP tendons treated with cd\u2010HA\u2010Lub was significantly lower than the nWOF of the untreated tendons (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The gliding resistance of cd\u2010HA\u2010Lub treated tendons was also significantly lower than that of the untreated tendons (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Surface treatment with cd\u2010HA\u2010Lub following flexor tendon repair provides an opportunity to improve outcomes for patients in whom the post\u2010operative therapy must be delayed after flexor tendon repair. \u00a9 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1940\u20131944, 2012<\/jats:p>","DOI":"10.1002\/jor.22177","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T17:10:24Z","timestamp":1340125824000},"page":"1940-1944","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Surface modification counteracts adverse effects associated with immobilization after flexor tendon repair"],"prefix":"10.1002","volume":"30","author":[{"given":"Chunfeng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Long","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Jay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Nan","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Amadio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(93)90312-Q"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2004.12.001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1197\/j.jht.2005.01.010"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318208d28e"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2004.11.005"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(80)80101-8"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/00325481.1986.11699559","article-title":"Emergency management of hand injuries. When to repair, when to refer","volume":"80","author":"Sturm JT","year":"1986","journal-title":"Postgrad Med"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2004.11.006"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181abb141"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100040116"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1054\/jhsb.1998.0212"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(94)90126-0"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200402000-00015"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1197\/j.jht.2005.04.017"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20731"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.00765"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","unstructured":"YangC AmadioP SunY et al.2003.Tendon surface modification by chemically modified HA coating after flexor digitorum profundus tendon repair. Transactions of the 49th Annual Meeting of Orthopedic Research Society New Orleans LA.","DOI":"10.1002\/jbm.b.10074"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.02.005"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2004.10.005"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01148"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199702000-00009"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194103000-00009"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197254030-00003"},{"key":"e_1_2_5_25_2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0030-5898(20)30822-1","article-title":"Primary repair of flexor tendons","volume":"4","author":"Kleinert HE","year":"1973","journal-title":"Orthop Clin North Am"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(77)80025-7"},{"key":"e_1_2_5_27_2","volume-title":"Rehabilitation of the Hand","author":"Duran RJ","year":"1978"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(89)90079-X"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2004.11.009"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldp013"},{"key":"e_1_2_5_31_2","first-page":"439","volume-title":"Rehabilitation of the hand","author":"Stewart MK","year":"2002"},{"key":"e_1_2_5_32_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0749-0712(21)01329-9","article-title":"Flexor tendon healing","volume":"1","author":"Manske PR","year":"1985","journal-title":"Hand Clin"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00168-1"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20624"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200111000-00015"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(82)80083-X"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20986"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/la702366t"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00045"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.00170.x"},{"key":"e_1_2_5_41_2","unstructured":"GlassonSS Rivera\u2010BermudezM TejadaJ et al.2009.Intra\u2010articular lubricin supplementation modifies disease progression and ameliorates pain in a rat model of osteoarthritis. 5th Annual Meeting of the Orthopaedic Research Society Poster No. 1116."},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200610000-00010"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678108992156"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198365010-00010"},{"key":"e_1_2_5_45_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00003086-198011000-00041","article-title":"The effects of mobilization on the vascularization of healing flexor tendons in dogs","volume":"153","author":"Gelberman RH","year":"1980","journal-title":"Clin Orthop"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.22177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:46:36Z","timestamp":1696909596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.22177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,19]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/jor.22177"],"URL":"https:\/\/doi.org\/10.1002\/jor.22177","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,19]]},"assertion":[{"value":"2012-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}