{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:44:02Z","timestamp":1780587842275,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T00:00:00Z","timestamp":1342137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Institutes of Health Research and Alberta Innovates Health Solutions"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We tested the hypothesis that immediate reattachment of the native anterior cruciate ligament (ACL) can prevent kinematic changes and the development of osteoarthritis (OA). Five sheep underwent anatomic unilateral ACL reconstruction (ACL\u2010R). Animals from a previous study served as sham (<jats:italic>n<\/jats:italic>\u2009=\u20097) or non\u2010operated (<jats:italic>n<\/jats:italic>\u2009=\u200917) controls. At 4 points of walking gait, 6 degrees of freedom stifle joint kinematics of ACL\u2010R animals were compared with sham controls at 4 and 20 weeks post\u2010surgery. Gross cartilage, bone, and meniscal changes were graded at euthanasia; paired and differential scores were compared. Inter\u2010animal differences were noted in all groups. Of 48 points of gait comparison between ACL\u2010R and sham operated groups, 42 points showed no difference (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Of the six significant differences (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), internal rotation in ACL\u2010R animals accounted for three. At 20 weeks, differential scores showed that sham operated joints were morphologically indistinguishable from non\u2010operated controls (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.129) while ACL\u2010R joints had significantly higher combined cartilage and osteophyte scores than those controls (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.003). This method of ACL reconstruction in sheep did not restore normal walking gait kinematics completely and allowed some OA to develop in operated joints. OA may result from relatively subtle mechanical abnormalities, apparently more so in some individuals than others. \u00a9 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:35\u201343, 2012<\/jats:p>","DOI":"10.1002\/jor.22187","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T22:39:40Z","timestamp":1342219180000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Osteoarthritis develops in the operated joint of an ovine model following ACL reconstruction with immediate anatomic reattachment of the native ACL"],"prefix":"10.1002","volume":"31","author":[{"given":"Etienne J.O.","family":"O'Brien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian E.","family":"Beveridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyla D.","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan J.","family":"Heard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Tapper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel G.","family":"Shrive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril B.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2009.04.066"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.02.010"},{"key":"e_1_2_6_4_2","first-page":"306","article-title":"Mechanical properties of PDS\u2010augmented patellar tendon transplants in reconstruction of the anterior cruciate ligament","volume":"95","author":"Holzmuller W","year":"1992","journal-title":"Unfallchirurg"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20051"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21549"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21404"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1695576"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/036354659101900308"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00119-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00126-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e31802bab3e"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00150"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.03.004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-008-0784-6"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.05.034"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-008-0763-y"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2010.09.012"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00034-7"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:JMSM.0000021109.21807.f0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2008.2609"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00033-5"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22187","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.22187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:13:59Z","timestamp":1697602439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.22187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,13]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1002\/jor.22187"],"URL":"https:\/\/doi.org\/10.1002\/jor.22187","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,13]]},"assertion":[{"value":"2012-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}