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Here, the physeal expression of bone morphogenetic proteins (BMPs) was investigated in a fracture\u2010animal model to test the hypothesis that a diaphyseal fracture stimulates the physeal expression of these known key regulators of bone formation, thus stimulating bone overgrowth. Sprague\u2013Dawley rats (male, 4 weeks old), were subjected to a unilateral mid\u2010diaphyseal tibial fracture. Kinetic expression of physeal BMP\u20102, \u20104, \u20106, \u20107, and BMP receptor\u20101a (BMPR\u20101a) was analyzed in a monthly period by quantitative real time\u2010polymerase chain reaction and immunohistochemistry. On Days 1, 3, 10, and 14 post\u2010fracture, no changes in physeal BMPs gene\u2010expression were detected. Twenty\u2010nine days post\u2010fracture, when the fracture was consolidated, physeal expression of BMP\u20106 and BMPR\u20101a was significantly upregulated in the growth plate of the fractured and contra\u2010lateral intact bone compared to control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005). This study demonstrates a late role of BMP\u20106 and BMPR\u20101a in fracture\u2010induced physeal growth alterations and furthermore, may have discovered the existence of a regulatory \u201ccross\u2010talk\u201d mechanism between the lower limbs whose function could be to limit leg\u2010length\u2010discrepancies following the breakage of growing bones. \u00a9 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 357\u2013363, 2013<\/jats:p>","DOI":"10.1002\/jor.22238","type":"journal-article","created":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T18:18:09Z","timestamp":1351016289000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["BMP\u20106 and BMPR\u20101a are up\u2010regulated in the growth plate of the fractured tibia"],"prefix":"10.1002","volume":"31","author":[{"given":"Eva E.","family":"Fischerauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Manninger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Seles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Janezic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Ebner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelie M.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,23]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"404","article-title":"Overgrowth of femoral fractures in childhood","volume":"89","author":"Jawish R","year":"2003","journal-title":"Rev Chir Orthop Reparatrice Appar Mot"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1982.tb06088.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678108992162"},{"key":"e_1_2_7_5_2","first-page":"684","article-title":"Femoral overgrowth following plate fixation of the fractured femur in children","volume":"47","author":"Sulaiman AR","year":"2006","journal-title":"Singapore Med J"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001320050524"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(40)90702-4"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-001-1047-1"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900249"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01202412-200110040-00014"},{"key":"e_1_2_7_11_2","first-page":"313","article-title":"Effect of femoral shaft fracture for growth of the lower extremity in children","volume":"68","author":"Zwierzchowski TJ","year":"2003","journal-title":"Chir Narzadow Ruchu Ortop Pol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1302\/0301-620X.68B4.3733825","article-title":"Overgrowth of the femur after fracture in childhood. 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