{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:33:43Z","timestamp":1782189223815,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sheep hips have a natural non\u2010spherical femoral head similar to a cam\u2010type deformity in human beings. By performing an intertrochanteric varus osteotomy, cam\u2010type femoro\u2010acetabular impingement (FAI) during flexion can be created. We tested the hypotheses that macroscopic lesions of the articular cartilage and an increased Mankin score (MS) can be reproduced by an experimentally induced cam\u2010type FAI in this ovine in vivo model. Furthermore, we hypothesized that the MS increases with longer ambulatory periods. Sixteen sheep underwent unilateral intertrochanteric varus osteotomy of the hip with the non\u2010operated hip as a control. Four sheep were sacrificed after 14, 22, 30, and 38\u2010weeks postoperatively. We evaluated macroscopic chondrolabral alterations, and recorded the MS, based on histochemical staining, for each ambulatory period. A significantly higher prevalence of macroscopic chondrolabral lesions was found in the impingement zone of the operated hips. The MS was significantly higher in the acetabular\/femoral cartilage of the operated hips. Furthermore, these scores increased as the length of the ambulatory period increased. Cam\u2010type FAI can be induced in an ovine in vivo model. Localized chondrolabral degeneration of the hip, similar to that seen in humans (Tannast et al., Clin Orthop Relat Res 2008; 466: 273\u2013280; Beck et al., J Bone Joint Surg Br 2005; 87: 1012\u20131018), can be reproduced. This experimental sheep model can be used to study cam\u2010type FAI. \u00a9 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 580\u2013587, 2013<\/jats:p>","DOI":"10.1002\/jor.22273","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T01:20:51Z","timestamp":1354152051000},"page":"580-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Experimentally induced cam impingement in the sheep hip"],"prefix":"10.1002","volume":"31","author":[{"given":"Klaus A.","family":"Siebenrock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Fiechter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Tannast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tallal C.","family":"Mamisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"von Rechenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/01.blo.0000096804.78689.c2","article-title":"Femorcetabular impingement: a cause for osteoarthritis of the hip","volume":"417","author":"Ganz R","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-007-0061-y"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.87B7.15203"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(03)00075-X"},{"key":"e_1_2_6_6_2","unstructured":"StulbergS CordellL HarrisW et al.1975.Unrecognized childhood hip disease: a major cause of idiopathic osteoarthritis of the hip. 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