{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:43:12Z","timestamp":1787236992748,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH-NIAMS grant","award":["P50 AR055533"],"award-info":[{"award-number":["P50 AR055533"]}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-10-1-0864, W81XWH-11-1-0583"],"award-info":[{"award-number":["W81XWH-10-1-0864, W81XWH-11-1-0583"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Medial meniscus destabilization (MMD) is a surgical insult technique for modeling osteoarthritis (OA) by replicating chronic abnormal cartilage loading in animal joints in vivo. The present study aimed to characterize the immediate biomechanical effects (ex vivo) and short\u2010term histological consequences (in vivo) of MMD in the rabbit knee. In a compressive loading test, contact stress distribution in the medial compartment was measured in eight cadaver rabbit knees, initially with all major joint structures uninjured (Baseline), after MMD, and finally after total medial meniscectomy (TMM). Similarly, the effects on sagittal joint stability were determined in an anterior\u2013posterior drawer test. These biomechanical (ex vivo) data indicated that both MMD and TMM caused significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), distinct (&gt;1.5\u2010fold) elevation of peak local contact stress in the medial compartment, while leaving whole\u2010joint stability nearly unchanged. Histological consequences in vivo were assessed in a short\u2010term (8\u2010week) survival series of MMD or TMM (five animals for each group), and both caused moderate cartilage degeneration in the medial compartment. The MMD insult, which is feasible through posterior arthrotomy alone, is as effective as TMM for modeling injurious\u2010level chronic abnormal cartilage loading in the rabbit knee medial compartment in vivo, while minimizing potential confounding effects from whole\u2010joint instability. \u00a9 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1555\u20131560, 2013.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.22393","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T08:01:00Z","timestamp":1373443260000},"page":"1555-1560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Replication of chronic abnormal cartilage loading by medial meniscus destabilization for modeling osteoarthritis in the rabbit knee in vivo"],"prefix":"10.1002","volume":"31","author":[{"given":"Marut","family":"Arunakul","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory University of Iowa 2181 Westlawn Iowa City Iowa 52242\u20101100"},{"name":"Department of Orthopaedic Surgery Thammasat University Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Tochigi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory University of Iowa 2181 Westlawn Iowa City Iowa 52242\u20101100"},{"name":"Department of Orthopaedics Dokkyo Medical University Koshigaya Hospital Koshigaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Goetz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory University of Iowa 2181 Westlawn Iowa City Iowa 52242\u20101100"},{"name":"Department of Biomedical Engineering University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce W.","family":"Diestelmeier","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory University of Iowa 2181 Westlawn Iowa City Iowa 52242\u20101100"},{"name":"Department of Biomedical Engineering University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneliese D.","family":"Heiner","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory University of Iowa 2181 Westlawn Iowa City Iowa 52242\u20101100"},{"name":"Department of Biomedical Engineering University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Rudert","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Orthopaedic Biomechanics Laboratory University of Iowa 2181 Westlawn Iowa City Iowa 52242\u20101100"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C.","family":"Fredericks","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and 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