{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:43:41Z","timestamp":1768002221173,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The cause of pain following rotator cuff tear has not been fully elucidated. The purpose of this study was to evaluate behavior and inflammatory cytokines in a rat unstabilized rotator cuff defect (UCD) model. Forty\u2010five Sprague\u2013Dawley rats were divided into three groups: sham; UCD; and stabilized rotator cuff defect (SCD). Gait analysis was examined using CatWalk. Tumor necrosis factor (TNF)\u2010\u03b1, interleukin(IL)\u20101\u03b2, and IL\u20106 were measured within the subacromial bursa and the glenohumeral joint synovium at 21 and 56 days after surgery using an enzyme\u2010linked immunosorbent assay (ELISA). Stride length, print area and contact intensity in the UCD group was significantly lower than in the sham group after surgery. Stride length, print area and contact intensity in the SCD group was significantly higher than in the UCD group. In contrast, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 in the UCD group was significantly higher than in the sham group at days 21 and 56. However, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 in the SCD group was significantly lower than in the UCD group at days 21 and 56. The present results suggest that SCD is effective not only in improving shoulder function but also in reducing inflammatory cytokines, which may serve as one source of pain due to rotator cuff tear. \u00a9 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:286\u2013290, 2014.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.22486","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T07:14:48Z","timestamp":1378710888000},"page":"286-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Assessment of pain\u2010related behavior and pro\u2010inflammatory cytokine levels in the rat rotator cuff tear model"],"prefix":"10.1002","volume":"32","author":[{"given":"Hironori","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyasu","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Kenmoku","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kitazato University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Ohtori","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Sasho","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhiro","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Kamoda","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumihisa","family":"Orita","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuu","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Kijima","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Chiba University After Graduate School of Medicine 1\u20108\u20101 Inohana Chuo\u2010ku Chiba 260\u20108670 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21266"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00835"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2005.05.017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2099"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102474\u201012\u2010144"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1058\u20102746(96)80070\u2010X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.10.031"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100160515"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736\u20100266(02)00063\u20103"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150150502613"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.537"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182269732"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2008.10.008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21361"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2011.03.076"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776\u2010011\u20100175\u20107"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22486","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.22486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:08:19Z","timestamp":1696392499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.22486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,9]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/jor.22486"],"URL":"https:\/\/doi.org\/10.1002\/jor.22486","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,9]]},"assertion":[{"value":"2013-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}