{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:22:03Z","timestamp":1787818923630,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AO Asia Pacific Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Kienb\u00f6ck's disease is idiopathic osteonecrosis of the lunate, leading to its fracture and collapse. This study compares internal and external bone micro\u2010architecture of normal and fractured lunates (Kienb\u00f6ck's), by using high\u2010resolution three\u2010dimensional (3D) micro\u2010computed tomography (micro\u2010CT) on the whole bone of the two lunate types, and histology.<\/jats:p><jats:p>Fractured Kienb\u00f6ck\u2010diseased lunates were obtained from patients undergoing proximal\u2010row\u2010carpectomy, while normal cadaveric lunates served as controls. 3D\u2010micro\u2010CT\u2010imaging of control lunates revealed an encircling cortex surrounding trabecular bone. Trabeculae were arranged in a radial pattern, spanning from the distal to the proximal subchondral plate. Kienb\u00f6ck's lunates exhibited clear fracture lines, with fragmented bone, both proximally and distally, in areas the radially\u2010patterned trabeculae and enveloping cortex were absent, producing height loss. In trabecular bone, Kienb\u00f6ck's lunates revealed increased bone volume fraction, trabecular thickness and number, and decreased trabecular separation and structure model index. Histologically, Kienb\u00f6ck's lunates revealed osteonecrosis, as well as remodeling fronts with osteoblasts and osteoid surrounding bone marrow. Whole\u2010bone high\u2010resolution 3D examination of normal and Kienb\u00f6ck's diseased lunates contributes to a better understanding of micro\u2010architectural changes occurring in the pathology. \u00a9 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:826\u2013833, 2014.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.22611","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T10:31:19Z","timestamp":1394447479000},"page":"826-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["External and internal bone micro\u2010architecture in normal and Kienb\u00f6ck's lunates: A whole\u2010bone micro\u2010computed tomography study"],"prefix":"10.1002","volume":"32","author":[{"given":"Stephanie C.","family":"Low","sequence":"first","affiliation":[{"name":"Discipline of Orthopaedics and Trauma The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory I.","family":"Bain","sequence":"additional","affiliation":[{"name":"Discipline of Orthopaedics and Trauma The University of Adelaide Adelaide South Australia Australia"},{"name":"Discipline of Anatomy and Pathology, School of Medical Sciences The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Findlay","sequence":"additional","affiliation":[{"name":"Discipline of Orthopaedics and Trauma The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Eng","sequence":"additional","affiliation":[{"name":"Discipline of Orthopaedics and Trauma The University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egon","family":"Perilli","sequence":"additional","affiliation":[{"name":"Discipline of Anatomy and Pathology, School of Medical Sciences The University of Adelaide Adelaide South Australia Australia"},{"name":"Medical Device Research Institute, School of Computer Science, Engineering and Mathematics Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410373703"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193411422337"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193409103732"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-225"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016922809176658"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(97)80004-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(80)80013-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00276-002-0065-y","article-title":"The venous drainage of the lunate bone","volume":"24","author":"Pichler M","year":"2002","journal-title":"Surg Radiol Anat"},{"key":"e_1_2_6_10_1","first-page":"215","article-title":"Significance of intraosseous pressure for pathogenesis of Kienbock disease","volume":"28","author":"Schiltenwolf M","year":"1996","journal-title":"Handchir Mikrochir Plast Chir"},{"key":"e_1_2_6_11_1","first-page":"168","article-title":"A vascular necrosis of the lunate and sickle cell anemia. 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