{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:18:53Z","timestamp":1791407933689,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":473,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Smart Mix Program of the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture and Science","award":["SSM06004"],"award-info":[{"award-number":["SSM06004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Orthop. Res."],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1002\/jor.22650","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T10:51:06Z","timestamp":1400237466000},"page":"1167-1174","source":"Crossref","is-referenced-by-count":84,"title":["Mesenchymal stem cells reduce pain but not degenerative changes in a mono-iodoacetate rat model of osteoarthritis"],"prefix":"10.1002","volume":"32","author":[{"given":"Gerben M.","family":"van Buul","sequence":"first","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"},{"name":"Department of Radiology; Erasmus MC; Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Siebelt","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten J. C.","family":"Leijs","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Koen","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Waarsing","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kops","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrie","family":"Weinans","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"},{"name":"Department of Biomechanical Engineering; Delft University of Technology; Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A. N.","family":"Verhaar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique R.","family":"Bernsen","sequence":"additional","affiliation":[{"name":"Department of Radiology; Erasmus MC; Rotterdam The Netherlands"},{"name":"Department of Nuclear Medicine; Erasmus MC; Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerjo J. V. M.","family":"van Osch","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics; Erasmus MC; Wytemaweg 80 Rotterdam The Netherlands"},{"name":"Department of Otorhinolaryngology; Erasmus MC; Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"10.1002\/jor.22650-BIB0001|jor22650-cit-0001","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.rdc.2008.05.006","article-title":"The role of analgesics and intra-articular injections in disease management","volume":"34","author":"Harvey","year":"2008","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1002\/jor.22650-BIB0002|jor22650-cit-0002","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1002\/jor.22650-BIB0003|jor22650-cit-0003","doi-asserted-by":"crossref","first-page":"e1886","DOI":"10.1371\/journal.pone.0001886","article-title":"Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1002\/jor.22650-BIB0004|jor22650-cit-0004","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/art.24443","article-title":"Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1","volume":"60","author":"Matsumoto","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jor.22650-BIB0005|jor22650-cit-0005","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00167-006-0124-8","article-title":"Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration","volume":"14","author":"Agung","year":"2006","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1002\/jor.22650-BIB0006|jor22650-cit-0006","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/art.11365","article-title":"Stem cell therapy in a caprine model of osteoarthritis","volume":"48","author":"Murphy","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jor.22650-BIB0007|jor22650-cit-0007","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/157488810790442796","article-title":"Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique","volume":"5","author":"Centeno","year":"2010","journal-title":"Curr Stem Cell Res Ther"},{"key":"10.1002\/jor.22650-BIB0008|jor22650-cit-0008","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/TP.0b013e318291a2da","article-title":"Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study","volume":"95","author":"Orozco","journal-title":"Transplantation"},{"key":"10.1002\/jor.22650-BIB0009|jor22650-cit-0009","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3727\/096368912X653264","article-title":"Intra-articular delivery of purified mesenchymal stem cells from C57BL\/6 or MRL\/MpJ superhealer mice prevents posttraumatic arthritis","volume":"22","author":"Diekman","journal-title":"Cell Transplant"},{"key":"10.1002\/jor.22650-BIB0010|jor22650-cit-0010","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1302\/0301-620X.88B9.17810","article-title":"Repair of chronic osteochondral defects in the rat. A bone marrow-stimulating procedure enhanced by cultured allogenic bone marrow mesenchymal stromal cells","volume":"88","author":"Nishimori","year":"2006","journal-title":"J Bone Joint Surg Br"},{"key":"10.1002\/jor.22650-BIB0011|jor22650-cit-0011","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/jor.20933","article-title":"Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis","volume":"27","author":"Frisbie","year":"2009","journal-title":"J Orthop Res"},{"key":"10.1002\/jor.22650-BIB0012|jor22650-cit-0012","doi-asserted-by":"crossref","first-page":"47","DOI":"10.22203\/eCM.v016a06","article-title":"Instant stem cell therapy: characterization and concentration of human mesenchymal stem cells in vitro","volume":"16","author":"Kasten","year":"2008","journal-title":"Eur Cell Mater"},{"key":"10.1002\/jor.22650-BIB0013|jor22650-cit-0013","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1063-4584(03)00163-8","article-title":"Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis","volume":"11","author":"Bove","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jor.22650-BIB0014|jor22650-cit-0014","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.joca.2013.07.002","article-title":"Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat","volume":"21","author":"Kelly","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jor.22650-BIB0015|jor22650-cit-0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/01.RES.0000135902.99383.6f","article-title":"Mesenchymal stem cells and their potential as cardiac therapeutics","volume":"95","author":"Pittenger","year":"2004","journal-title":"Circ Res"},{"key":"10.1002\/jor.22650-BIB0016|jor22650-cit-0016","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/path.2469","article-title":"Why are MSCs therapeutic? New data: new insight","volume":"217","author":"Caplan","year":"2009","journal-title":"J Pathol"},{"key":"10.1002\/jor.22650-BIB0017|jor22650-cit-0017","doi-asserted-by":"crossref","first-page":"250978","DOI":"10.4061\/2010\/250978","article-title":"Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon","volume":"2010","author":"Crovace","year":"2010","journal-title":"Vet Med Int"},{"key":"10.1002\/jor.22650-BIB0018|jor22650-cit-0018","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1359\/JBMR.040705","article-title":"An improved segmentation method for in vivo microCT imaging","volume":"19","author":"Waarsing","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1002\/jor.22650-BIB0019|jor22650-cit-0019","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1002\/art.30307","article-title":"Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an in vivo microfocal computed tomography study","volume":"63","author":"Botter","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jor.22650-BIB0020|jor22650-cit-0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3109\/10520299309105572","article-title":"Thionin staining of paraffin and plastic embedded sections of cartilage","volume":"68","author":"Bulstra","year":"1993","journal-title":"Biotech Histochem"},{"key":"10.1002\/jor.22650-BIB0021|jor22650-cit-0021","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00489922","article-title":"Limitations of safranin \u2018O\u2019 staining in proteoglycan-depleted cartilage demonstrated with monoclonal antibodies","volume":"89","author":"Camplejohn","year":"1988","journal-title":"Histochemistry"},{"key":"10.1002\/jor.22650-BIB0022|jor22650-cit-0022","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jor.22650-BIB0023|jor22650-cit-0023","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/jor.21444","article-title":"Quantifying osteoarthritic cartilage changes accurately using in vivo microCT arthrography in three etiologically distinct rat models","volume":"29","author":"Siebelt","year":"2011","journal-title":"J Orthop Res"},{"key":"10.1002\/jor.22650-BIB0024|jor22650-cit-0024","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1002\/art.11328","article-title":"Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta\/bone morphogenetic protein inhibitors during experimental osteoarthritis","volume":"48","author":"Scharstuhl","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jor.22650-BIB0025|jor22650-cit-0025","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/cmmi.1513","article-title":"In vivo quantitative assessment of cell viability of gadolinium or iron-labeled cells using MRI and bioluminescence imaging","volume":"8","author":"Guenoun","year":"2013","journal-title":"Contrast Media Mol Imaging"},{"key":"10.1002\/jor.22650-BIB0026|jor22650-cit-0026","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/cmmi.289","article-title":"Ferumoxides-protamine sulfate is more effective than ferucarbotran for cell labeling: implications for clinically applicable cell tracking using MRI","volume":"4","author":"van Buul","year":"2009","journal-title":"Contrast Media Mol Imaging"},{"key":"10.1002\/jor.22650-BIB0027|jor22650-cit-0027","first-page":"39","article-title":"In vivo micro computed tomography of subchondral bone in the rat after intra-articular administration of monosodium iodoacetate","volume":"43","author":"Morenko","year":"2004","journal-title":"Contemp Top Lab Anim Sci"},{"key":"10.1002\/jor.22650-BIB0028|jor22650-cit-0028","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.joca.2007.08.005","article-title":"Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis","volume":"16","author":"Botter","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1002\/jor.22650-BIB0029|jor22650-cit-0029","first-page":"192","article-title":"Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs","volume":"9","author":"Black","year":"2008","journal-title":"Vet Ther"},{"key":"10.1002\/jor.22650-BIB0030|jor22650-cit-0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2474-12-134","article-title":"Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain","volume":"12","author":"Orita","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1002\/jor.22650-BIB0031|jor22650-cit-0031","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1744-8069-3-8","article-title":"Techniques for assessing knee joint pain in arthritis","volume":"3","author":"Neugebauer","year":"2007","journal-title":"Mol Pain"},{"key":"10.1002\/jor.22650-BIB0032|jor22650-cit-0032","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/1471-2474-14-228","article-title":"Low dose native type II collagen prevents pain in a rat osteoarthritis model","volume":"14","author":"Di Cesare Mannelli","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1002\/jor.22650-BIB0033|jor22650-cit-0033","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0301-472X(03)00110-3","article-title":"HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells","volume":"31","author":"Le Blanc","year":"2003","journal-title":"Exp Hematol"},{"key":"10.1002\/jor.22650-BIB0034|jor22650-cit-0034","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-pathol-011110-130230","article-title":"Mesenchymal stem cells: mechanisms of inflammation","volume":"6","author":"Singer","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"10.1002\/jor.22650-BIB0035|jor22650-cit-0035","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1089\/hum.2011.039","article-title":"Immunological aspects of allogeneic and autologous mesenchymal stem cell therapies","volume":"22","author":"Hoogduijn","year":"2011","journal-title":"Hum Gene Ther"},{"key":"10.1002\/jor.22650-BIB0036|jor22650-cit-0036","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1089\/hum.2010.156","article-title":"Immunological aspects of allogeneic mesenchymal stem cell therapies","volume":"21","author":"Griffin","year":"2010","journal-title":"Hum Gene Ther"},{"key":"10.1002\/jor.22650-BIB0037|jor22650-cit-0037","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/j.1582-4934.2011.01509.x","article-title":"Immunogenicity of allogeneic mesenchymal stem cells","volume":"16","author":"Schu","year":"2011","journal-title":"J Cell Mol Med"},{"key":"10.1002\/jor.22650-BIB0038|jor22650-cit-0038","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/art.37960","article-title":"Long-term detection of human adipose-derived mesenchymal stem cells after intraarticular injection in SCID mice","volume":"65","author":"Toupet","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1002\/jor.22650-BIB0039|jor22650-cit-0039","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.knee.2010.03.001","article-title":"Treatment of osteoarthritis with infrapatellar fat pad derived mesenchymal stem cells in Rabbit","volume":"18","author":"Toghraie","year":"2010","journal-title":"Knee"},{"key":"10.1002\/jor.22650-BIB0040|jor22650-cit-0040","doi-asserted-by":"crossref","first-page":"C675","DOI":"10.1152\/ajpcell.00437.2007","article-title":"Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism","volume":"294","author":"Crisostomo","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1002\/jor.22650-BIB0041|jor22650-cit-0041","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.exphem.2005.05.002","article-title":"Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells","volume":"33","author":"Groh","year":"2005","journal-title":"Exp Hematol"},{"key":"10.1002\/jor.22650-BIB0042|jor22650-cit-0042","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.arthro.2011.06.002","article-title":"Evaluation of intra-articular mesenchymal stem cells to augment healing of microfractured chondral defects","volume":"27","author":"McIlwraith","year":"2011","journal-title":"Arthroscopy"},{"key":"10.1002\/jor.22650-BIB0043|jor22650-cit-0043","doi-asserted-by":"crossref","first-page":"e10088","DOI":"10.1371\/journal.pone.0010088","article-title":"A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype","volume":"5","author":"Waterman","year":"2010","journal-title":"PLoS ONE"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22650","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jor.22650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T11:29:56Z","timestamp":1625484596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.22650"}},"subtitle":["STEM CELL THERAPY FOR OSTEOARTHRITIS"],"short-title":[],"issued":{"date-parts":[[2014,5,16]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"URL":"https:\/\/doi.org\/10.1002\/jor.22650","archive":["Portico"],"relation":{},"ISSN":["0736-0266"],"issn-type":[{"value":"0736-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5,16]]}}}