{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:01:20Z","timestamp":1791860480308,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":384,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Orthopaedic Research and Education Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Orthop. Res."],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1002\/jor.22714","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T21:33:36Z","timestamp":1407965616000},"page":"1562-1571","source":"Crossref","is-referenced-by-count":23,"title":["Osteoclast inhibition impairs chondrosarcoma growth and bone destruction"],"prefix":"10.1002","volume":"32","author":[{"given":"Jesse E.","family":"Otero","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery; University of Iowa; 200 Hawkins Drive, 01051 JPP Iowa City Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff W.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine; University of Iowa School of Medicine; 500 Newton Road, Bldg. Medical Laboratories 3160 Iowa City IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison E.","family":"Malandra","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Bone Healing Research Laboratory; University of Iowa; 2662 Crosspark Road, MTP 4 Coralville Iowa 52241"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C.","family":"Fredericks","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Bone Healing Research Laboratory; University of Iowa; 2662 Crosspark Road, MTP 4 Coralville Iowa 52241"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Odgren","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, S7-242; University of Massachusetts Medical School; 55 Lake Ave North North Worcester MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Buckwalter","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery; University of Iowa; 200 Hawkins Drive, 01023 JPP Iowa City Iowa 52242"},{"name":"Iowa City Veterans Administration Medical Center; 601 Highway 6 West Iowa City Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Morcuende","sequence":"additional","affiliation":[{"name":"University of Iowa Department of Orthopaedic Surgery; 200 Hawkins Drive, 01023 JPP Iowa City Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"10.1002\/jor.22714-BIB0001|jor22714-cit-0001","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1053\/j.semdp.2011.02.002","article-title":"Primary malignant bone tumors-recent developments","volume":"28","author":"Hameed","year":"2011","journal-title":"Semin Diagn Pathol"},{"key":"10.1002\/jor.22714-BIB0002|jor22714-cit-0002","doi-asserted-by":"crossref","first-page":"405437","DOI":"10.1155\/2011\/405437","article-title":"Chondrosarcoma: with updates on molecular genetics","volume":"2011","author":"Kim","year":"2011","journal-title":"Sarcoma"},{"key":"10.1002\/jor.22714-BIB0003|jor22714-cit-0003","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.bbrc.2006.05.158","article-title":"Intrinsic radiation resistance in human chondrosarcoma cells","volume":"346","author":"Moussavi-Harami","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/jor.22714-BIB0004|jor22714-cit-0004","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1302\/0301-620X.87B11.16621","article-title":"Surgical treatment and outcome of conventional pelvic chondrosarcoma","volume":"87","author":"Donati","year":"2005","journal-title":"J Bone Joint Surg Br"},{"key":"10.1002\/jor.22714-BIB0005|jor22714-cit-0005","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2106\/00004623-199903000-00004","article-title":"Chondrosarcoma of bone: an assessment of outcome","volume":"81","author":"Lee","year":"1999","journal-title":"J Bone Joint Surg Am"},{"key":"10.1002\/jor.22714-BIB0006|jor22714-cit-0006","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.2106\/00004623-200111000-00003","article-title":"Chondrosarcoma of the pelvis. A review of sixty-four cases","volume":"83-A","author":"Pring","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1002\/jor.22714-BIB0007|jor22714-cit-0007","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/(SICI)1097-0142(19960815)78:4<745::AID-CNCR9>3.0.CO;2-D","article-title":"Chondrosarcoma of the pelvis. Prognostic factors for 67 patients treated with definitive surgery","volume":"78","author":"Sheth","year":"1996","journal-title":"Cancer"},{"key":"10.1002\/jor.22714-BIB0008|jor22714-cit-0008","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/1097-0142(19800101)45:1<149::AID-CNCR2820450125>3.0.CO;2-A","article-title":"Chondrosarcoma: a clinicopathologic and statistical analysis","volume":"45","author":"Pritchard","year":"1980","journal-title":"Cancer"},{"key":"10.1002\/jor.22714-BIB0009|jor22714-cit-0009","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1155\/2000\/635246","article-title":"Chondrosarcoma of the pelvis: oncologic and functional outcome","volume":"4","author":"Wirbel","year":"2000","journal-title":"Sarcoma"},{"key":"10.1002\/jor.22714-BIB0010|jor22714-cit-0010","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2353\/ajpath.2007.060834","article-title":"Osteoclasts: what do they do and how do they do it","volume":"170","author":"Teitelbaum","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1002\/jor.22714-BIB0011|jor22714-cit-0011","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1186\/1471-2407-10-471","article-title":"Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors","volume":"10","author":"Hamm","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1002\/jor.22714-BIB0012|jor22714-cit-0012","first-page":"5093","article-title":"Histological and biochemical studies of a transplantable rat chondrosarcoma","volume":"39","author":"Breitkreutz","year":"1979","journal-title":"Cancer Res"},{"key":"10.1002\/jor.22714-BIB0013|jor22714-cit-0013","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/ijc.21951","article-title":"Zoledronic acid slows down rat primary chondrosarcoma development, recurrent tumor progression after intralesional curretage and increases overall survival","volume":"119","author":"Gouin","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1002\/jor.22714-BIB0014|jor22714-cit-0014","doi-asserted-by":"crossref","first-page":"14303","DOI":"10.1073\/pnas.202332999","article-title":"The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification","volume":"99","author":"Van Wesenbeeck","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/jor.22714-BIB0015|jor22714-cit-0015","first-page":"46","article-title":"Swarm rat chondrosarcoma cells as an in vivo model: lung colonization and effects of tissue environment on tumor growth","volume":"32","author":"Morcuende","year":"2012","journal-title":"Iowa Orthop J"},{"key":"10.1002\/jor.22714-BIB0016|jor22714-cit-0016","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/jor.1100090317","article-title":"Experimental transplantation of the Swarm rat chondrosarcoma into bone: radiological and pathological studies","volume":"9","author":"Kenan","year":"1991","journal-title":"J Orthop Res"},{"key":"10.1002\/jor.22714-BIB0017|jor22714-cit-0017","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1056\/NEJMoa0806285","article-title":"Endocrine therapy plus zoledronic acid in premenopausal breast cancer","volume":"360","author":"Gnant","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1002\/jor.22714-BIB0018|jor22714-cit-0018","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/sj.bjc.6602551","article-title":"Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration","volume":"92","author":"Wardley","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1002\/jor.22714-BIB0019|jor22714-cit-0019","first-page":"1103","article-title":"Bone remodelling and tumour grade modifications induced by interactions between bone and swarm rat chondrosarcoma","volume":"17","author":"Grimaud","year":"2002","journal-title":"Histol Histopathol"},{"key":"10.1002\/jor.22714-BIB0020|jor22714-cit-0020","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ar.1092000307","article-title":"The ultrastructure of cultures from the Swarm rat chondrosarcoma","volume":"200","author":"Hascall","year":"1981","journal-title":"Anat Rec"},{"key":"10.1002\/jor.22714-BIB0021|jor22714-cit-0021","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1016\/S0021-9258(17)30114-X","article-title":"Biosynthesis of proteoglycans and their assembly into aggregates in cultures of chondrocytes from the Swarm rat chondrosarcoma","volume":"254","author":"Kimura","year":"1979","journal-title":"J Biol Chem"},{"key":"10.1002\/jor.22714-BIB0022|jor22714-cit-0022","first-page":"362","article-title":"Transplantable osteogenic tumor in the rat","volume":"27","author":"Maibenco","year":"1967","journal-title":"Cancer Res"},{"key":"10.1002\/jor.22714-BIB0023|jor22714-cit-0023","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1148\/rg.235035134","article-title":"From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation","volume":"23","author":"Murphey","year":"2003","journal-title":"Radiographics"},{"key":"10.1002\/jor.22714-BIB0024|jor22714-cit-0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/932451","article-title":"The bone niche of chondrosarcoma: a sanctuary for drug resistance, tumour growth and also a source of new therapeutic targets","volume":"2011","author":"David","year":"2011","journal-title":"Sarcoma"},{"key":"10.1002\/jor.22714-BIB0025|jor22714-cit-0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2011.03.774","article-title":"The relationship between the chemistry and biological activity of the bisphosphonates","author":"Ebetino","year":"2011","journal-title":"Bone"},{"key":"10.1002\/jor.22714-BIB0026|jor22714-cit-0026","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrendo.2010.227","article-title":"Bone metastasis: mechanisms and therapeutic opportunities","volume":"7","author":"Suva","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"10.1002\/jor.22714-BIB0027|jor22714-cit-0027","first-page":"9","article-title":"Indian hedgehog signaling pathway differences between swarm rat chondrosarcoma and native rat chondrocytes","volume":"27","author":"Oji","year":"2007","journal-title":"Iowa Orthop J"},{"key":"10.1002\/jor.22714-BIB0028|jor22714-cit-0028","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/2191-219X-3-40","article-title":"99mTc-NT P 15-5 assessment of the early therapeutic response of chondrosarcoma to zoledronic acid in the Swarm rat orthotopic model","volume":"3","author":"Miot-Noirault","year":"2013","journal-title":"EJNMMI Res"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22714","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jor.22714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:59:12Z","timestamp":1649937552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.22714"}},"subtitle":["CHONDROSARCOMA GROWTH AND BONE DESTRUCTION"],"short-title":[],"issued":{"date-parts":[[2014,8,13]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"URL":"https:\/\/doi.org\/10.1002\/jor.22714","relation":{},"ISSN":["0736-0266"],"issn-type":[{"value":"0736-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8,13]]}}}