{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T02:35:58Z","timestamp":1773542158213,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The purpose of this study was to examine the effect of tenascin\u2010C (TNC) on the repair of full\u2010thickness osteochondral defects of articular cartilage in vivo. We used a gellan\u2013gellan\u2013sulfate sponge (Gellan\u2013GS) to maintain a TNC\u2010rich environment in the cartilage defects. We implanted Gellan\u2010GS soaked in PBS only (Group 1), Gellan\u2010GS soaked in 10\u2009\u00b5g\/ml of TNC (Group 2), and Gellan\u2010GS soaked in 100\u2009\u00b5g\/ml of TNC (Group 3) into a full\u2010thickness osteochondral defect of the patellar groove of rabbits. The defect area was examined grossly and histologically 4\u201312 weeks after surgery. Sections of synovium were also immunohistochemically investigated. Histologically as well as macroscopically, the defects in Group 2 showed better repair than the other groups at 8 and 12 weeks after surgery. Inflammation of the synovium tended to diminish over time in all groups, and the degree of synovitis was the same for all three groups at each time point. In conclusion, Gellan\u2013GS soaked in TNC can be used as a novel scaffold for the repair of articular cartilage defects. This study also indicates that TNC promotes the repair of full\u2010thickness osteochondral defects in vivo. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. 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