{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:16:00Z","timestamp":1789895760555,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Conselleria d\u00e2\u20ac\u2122Educaci\u00c3\u00b3, Cultura i Universitat (Govern de les Illes Balears","award":["9\/2011"],"award-info":[{"award-number":["9\/2011"]}]},{"name":"FEDER funds (European Union)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Calcific tendinopathy of the tendons of the rotator cuff is common in adults. These calcifications tend to be reabsorbed after a period of acute pain. This study evaluated the morphologic characteristics of calcific deposits and the participation of phytate and osteopontin (OPN) in their development. Calcific deposits were removed from 21 patients with calcific tendinopathy by ultrasound\u2010guided needle puncture under local anesthesia. The removed deposits were evaluated by scanning electron microscopy, X\u2010ray diffraction and Fourier transform infrared spectroscopy. The amounts of calcium and phosphorus in the deposits were semi\u2010quantitatively determined by energy dispersive X\u2010ray analysis. Phytate was determined in 2\u2009h urine samples, and OPN was extracted from a pool of deposits. The calcific deposits consisted of amorphous and poorly crystalline carbonated hydroxyapatite containing molecular water and organic matter. OPN was associated with the hydroxyapatite deposits. Phytate concentrations were significantly lower in the urine of patients with calcific tendinopathy than in healthy controls. The deficit in crystallization inhibitors such as phytate, and the presence of regulators such as OPN, may play important roles in the development of calcific tendinopathy. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:475\u2013482, 2015.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.22801","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T11:46:39Z","timestamp":1418211999000},"page":"475-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Characterization of deposits in patients with calcific tendinopathy of the supraspinatus. Role of phytate and osteopontin"],"prefix":"10.1002","volume":"33","author":[{"given":"Felix","family":"Grases","sequence":"first","affiliation":[{"name":"Laboratory of Renal Lithiasis Research University Institute of Health Sciences Research (IUNICS\u2010IdISPa) Universitat de les Illes Balears Palma de Mallorca Spain"},{"name":"CIBERobn (CB06\/03) Instituto de Salud Carlos III Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Muntaner\u2010Gimbernat","sequence":"additional","affiliation":[{"name":"Radiology Department Son Espases University Hospital Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Vilchez\u2010Mira","sequence":"additional","affiliation":[{"name":"Radiology Department Son Espases University Hospital Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Costa\u2010Bauz\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Lithiasis Research University Institute of Health Sciences Research (IUNICS\u2010IdISPa) Universitat de les Illes Balears Palma de Mallorca Spain"},{"name":"CIBERobn (CB06\/03) Instituto de Salud Carlos III Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Tur","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Lithiasis Research University Institute of Health Sciences Research (IUNICS\u2010IdISPa) Universitat de les Illes Balears Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafel Maria","family":"Prieto","sequence":"additional","affiliation":[{"name":"Laboratory of Renal Lithiasis Research University Institute of Health Sciences Research (IUNICS\u2010IdISPa) Universitat de les Illes Balears Palma de Mallorca Spain"},{"name":"CIBERobn (CB06\/03) Instituto de Salud Carlos III Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margalida","family":"Torrens\u2010Mas","sequence":"additional","affiliation":[{"name":"Biology and Health Sciences Department Universitat de les Illes Balears Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Gisela","family":"Vega","sequence":"additional","affiliation":[{"name":"Radiology Department Son Espases University Hospital Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1941.02820220019004"},{"key":"e_1_2_6_3_1","first-page":"325","article-title":"Calcifications of the shoulder. 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