{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:18:34Z","timestamp":1790615914650,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Marshall University, Joan C. Edwards School of Medicine (MUSOM) Anatomy and Pathology"},{"name":"Marshall University ADVANCE","award":["NSF 0929997"],"award-info":[{"award-number":["NSF 0929997"]}]},{"DOI":"10.13039\/100005768","name":"NASA WV Space Grant Consortium","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005768","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Kentucky CCTS Pilot Program","award":["NIH UL1TR000117"],"award-info":[{"award-number":["NIH UL1TR000117"]}]},{"name":"National Science Foundation","award":["MRI-R2 0959012"],"award-info":[{"award-number":["MRI-R2 0959012"]}]},{"name":"ASBMR Grants in Aid Program"},{"name":"NIH\/NIAMS","award":["1R15AR067451-01"],"award-info":[{"award-number":["1R15AR067451-01"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Linear growth failure results from a broad spectrum of systemic and local disorders that can generate chronic musculoskeletal disability. Current bone lengthening protocols involve invasive surgeries or drug regimens, which are only partially effective. Exposure to warm ambient temperature during growth increases limb length, suggesting that targeted heat could noninvasively enhance bone elongation. We tested the hypothesis that daily heat exposure on one side of the body unilaterally increases femoral and tibial lengths. Mice (<jats:italic>N<\/jats:italic>\u2009=\u200920) were treated with 40\u2009\u00b0C unilateral heat for 40\u2009min\/day for 14 days post\u2010weaning. Non\u2010treated mice (<jats:italic>N<\/jats:italic>\u2009=\u20096) served as controls. Unilateral increases in ear (8.8%), hindfoot (3.5%), femoral (1.3%), and tibial (1.5%) lengths were obtained. Tibial elongation rate was &gt;\u200912% greater (15\u2009\u03bcm\/day) on the heat\u2010treated side. Extremity lengthening correlated with temperature during treatment. Body mass and humeral length were unaffected. To test whether differences persisted in adults, mice were examined 7\u2010weeks post\u2010treatment. Ear area, hindfoot, femoral, and tibial lengths were still significantly increased \u223c6%, 3.5%, 1%, and 1%, respectively, on the heat\u2010treated side. Left\u2010right differences were absent in non\u2010treated controls, ruling out inherent side asymmetry. This model is important for designing noninvasive heat\u2010based therapies to potentially combat a range of debilitating growth impediments in children. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:692\u2013698, 2015.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jor.22812","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T21:23:13Z","timestamp":1422652993000},"page":"692-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Unilateral heat accelerates bone elongation and lengthens extremities of growing mice"],"prefix":"10.1002","volume":"33","author":[{"given":"Maria A.","family":"Serrat","sequence":"first","affiliation":[{"name":"Department of Anatomy and Pathology Joan C. Edwards School of Medicine Marshall University Huntington West Virginia 25704"},{"name":"Department of Orthopaedics Joan C. Edwards School of Medicine Marshall University Huntington West Virginia 25701"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Schlierf","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Joan C. 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