{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T08:07:06Z","timestamp":1783843626873,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This study aimed to evaluate the time course of local changes during the acute phase of gastrocnemius muscle strain, in a rat model, using an in vivo imaging system. Thirty\u2010eight, 8\u2010week\u2010old Sprague\u2010Dawley male rats were used in our study. Experimental injury of the right gastrocnemius muscle was achieved using the drop\u2010mass method. After inducing muscle injury, a liposomally formulated indocyanine green derivative (LP\u2010iDOPE, 7\u2009mg\/kg) was injected intraperitoneally. We evaluated the muscle injuries using in vivo imaging, histological examinations, and enzyme\u2010linked immunosorbent assays. The fluorescence peaked approximately 18\u2009h after the injury, and decreased thereafter. Histological examinations revealed that repair of the injured tissue occurred between 18 and 24\u2009h after injury. Quantitative analyses for various cytokines demonstrated significant elevations of interleukin\u20106 and tumor necrosis factor\u2010\u03b1 at 3 and 18\u2009h post\u2010injury, respectively. The time course of fluorescence intensity, measured using in vivo imaging, demonstrated that the changes in cytokine levels and histopathologic characteristics were consistent. Specifically, these changes reached peaked 18\u2009h post\u2010injury, followed by trends toward recovery. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1034\u20131038, 2015.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.22832","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T16:50:57Z","timestamp":1425315057000},"page":"1034-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Longitudinal evaluation of local muscle conditions in a rat model of gastrocnemius muscle injury using an in vivo imaging system"],"prefix":"10.1002","volume":"33","author":[{"given":"Kazuhide","family":"Inage","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Graduate School of Medicine, Chiba University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery National Hospital Organization Chiba Medical Center Chiba 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