{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:59Z","timestamp":1792782299394,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NIAMS","award":["AR049823\/AR062613"],"award-info":[{"award-number":["AR049823\/AR062613"]}]},{"name":"Erasmus"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Dynamics of structures within the carpal tunnel may alter in carpal tunnel syndrome (CTS) due to fibrotic changes and increased carpal tunnel pressure. Ultrasound can visualize these potential changes, making ultrasound potentially an accurate diagnostic tool. To study this, we imaged the carpal tunnel of 113 patients and 42 controls. CTS severity was classified according to validated clinical and nerve conduction study (NCS) classifications. Transversal and longitudinal displacement and shape (changes) were calculated for the median nerve, tendons and surrounding tissue. To predict diagnostic value binary logistic regression modeling was applied. Reduced longitudinal nerve displacement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2264\u20090.019), increased nerve cross\u2010sectional area (\n                      <jats:italic>p<\/jats:italic>\n                      \u2264\u20090.006) and perimeter (\n                      <jats:italic>p<\/jats:italic>\n                      \u2264\u20090.007), and a trend of relatively changed tendon displacements were seen in patients. Changes were more convincing when CTS was classified as more severe. Binary logistic modeling to diagnose CTS using ultrasound showed a sensitivity of 70\u201371% and specificity of 80\u201384%. In conclusion, CTS patients have altered dynamics of structures within the carpal tunnel. \u00a9 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1332\u20131340, 2015.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jor.22909","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T20:26:12Z","timestamp":1428697572000},"page":"1332-1340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Multidimensional ultrasound imaging of the wrist: Changes of shape and displacement of the median nerve and tendons in carpal tunnel syndrome"],"prefix":"10.1002","volume":"33","author":[{"given":"Anika","family":"Filius","sequence":"first","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Hand Surgery Erasmus MC University Medical Centre Rotterdam Netherlands"},{"name":"Department of Rehabilitation Medicine Erasmus MC Rotterdam The Netherlands"},{"name":"Biomechanics Laboratory Division of Orthopedic Research Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans G.","family":"Bosch","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk J.","family":"Stam","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E. R.","family":"Hovius","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Hand Surgery Erasmus MC University Medical Centre Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Amadio","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory Division of Orthopedic Research Department of Orthopedic Surgery Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud W.","family":"Selles","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Hand Surgery Erasmus MC University Medical Centre Rotterdam Netherlands"},{"name":"Department of Rehabilitation Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.203"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000338533.88960.b9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880161220"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2004.34.10.565"},{"key":"e_1_2_7_7_1","first-page":"118","article-title":"Ultrasound imaging for the rheumatologist II. Ultrasonography of the hand and wrist","volume":"24","author":"Filippucci E","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_8_1","first-page":"78","article-title":"Ultrasound examination of the wrist","volume":"80","author":"Ferrara MA","year":"1997","journal-title":"J Belge Radiol"},{"key":"e_1_2_7_9_1","first-page":"454","article-title":"The current role of high\u2010resolution ultrasonography of the hand and wrist in rheumatic diseases","volume":"16","author":"Van Vugt RM","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_10_1","first-page":"375","article-title":"Ultrasound changes in the wrist and hand in hemodialysis patients","volume":"48","author":"Lanteri M","year":"1997","journal-title":"Clin Nephrol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1061-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23426"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20551"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.115337"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23246"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23789"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23788"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037081"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2013.12.012"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.02.015"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00704-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199311000-00002"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1997.tb00271.x"},{"key":"e_1_2_7_24_1","volume-title":"Manual of nerve conduction studies","author":"Buschbacher RM","year":"2006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1589"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.01.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-210X.2011.00125.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21131"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2007.09.017"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(05)80153-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(92)90091-F"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.main.2010.04.002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.7.1091"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23912"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20125"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.1.23"},{"key":"e_1_2_7_37_1","volume-title":"Statistical methods for rates & proportions","author":"Fleiss JL.","year":"2004"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22909","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.22909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.22909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:14:01Z","timestamp":1696378441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.22909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/jor.22909"],"URL":"https:\/\/doi.org\/10.1002\/jor.22909","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]},"assertion":[{"value":"2014-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}